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    Recovery and survival from aging-associated diseases. 

    Akushevich, Igor; Arbeev, Konstantin; Kravchenko, J; Ukraintseva, Svetlana; Yashin, Anatoli I (Exp Gerontol, 2013-08)
    OBJECTIVES: Considering disease incidence to be a main contributor to healthy lifespan of the US elderly population may lead to erroneous conclusions when recovery/long-term remission factors are underestimated. Using two ...
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    Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. 

    Arbeev, Konstantin; Aviv, A; Hunt, SC; Kimura, M; Yashin, Anatoli I (Mech Ageing Dev, 2011-04)
    Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring of older fathers. Longer telomeres might increase cancer risk. We examined the relation of father's age at the birth of the offspring ...
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    Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages. 

    Bolund, L; Chen, H; Feng, L; Gottschalk, William Kirby; Gregory, Simon Gray; Gu, J; Hauser, Elizabeth Rebecca; ... (29 authors) (Rejuvenation Res, 2016-06)
    On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes ...
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    GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. 

    Bolund, L; Chen, H; Cheng, L; Feng, L; Gu, J; Hauser, Elizabeth Rebecca; Land, Kenneth C; ... (21 authors) (J Gerontol A Biol Sci Med Sci, 2015-04)
    Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time ...
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    Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study. 

    Arbeev, Konstantin; Culminskaya, IV; Kulminski, Alexander; Province, MA; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Rejuvenation Res, 2015-04)
    The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex. One complicating factor is genetic trade-off. Here we focused ...
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    Medical cost trajectories and onsets of cancer and noncancer diseases in US elderly population. 

    Akushevich, Igor; Akushevich, L; Arbeev, Konstantin; Kravchenko, J; Ukraintseva, Svetlana; Yashin, Anatoli I (Comput Math Methods Med, 2011)
    Time trajectories of medical costs-associated with onset of twelve aging-related cancer and chronic noncancer diseases were analyzed using the National Long-Term Care Survey data linked to Medicare Service Use files. A special ...
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    Cardiovascular comorbidities and survival of lung cancer patients: Medicare data based analysis. 

    Akushevich, Igor; Arbeev, Konstantin; Berry, Mark Francis; Kravchenko, J; Lyerly, Herbert Kim; Yashin, Anatoli I (Lung Cancer, 2017-06-05)
    OBJECTIVES: To evaluate the role of cardiovascular disease (CVD) comorbidity in survival of patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: The impact of seven CVDs (at the time of NSCLC diagnosis ...
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    A new algorithm for predicting time to disease endpoints in Alzheimer's disease patients. 

    Albert, M; Blacker, D; Brandt, J; Kinosian, B; Razlighi, QR; Scarmeas, N; Stallard, Eric; ... (9 authors) (J Alzheimers Dis, 2014)
    BACKGROUND: The ability to predict the length of time to death and institutionalization has strong implications for Alzheimer's disease patients and caregivers, health policy, economics, and the design of intervention studies. ...
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    Health and function of participants in the Long Life Family Study: A comparison with other cohorts. 

    Barral, S; Christensen, Kaare; Glynn, NW; Hadley, E; Lee, JH; Mayeux, R; Newman, Anne B; ... (14 authors) (Aging (Albany NY), 2011-01)
    Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort ...
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    Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children. 

    Arbeev, Konstantin; Barmada, M; Christensen, Kaare; Kulminski, Alexander; Miljkovic, I; Stallard, Eric; Yashin, Anatoli I (J Gerontol A Biol Sci Med Sci, 2013-07)
    This study focuses on the participants of the Long Life Family Study to elucidate whether biogenetic mechanisms underlying relationships among heritable complex phenotypes in parents function in the same way for the same ...
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    Author
    Yashin, Anatoli I (15)
    Arbeev, Konstantin (11)Ukraintseva, Svetlana (7)Akushevich, Igor (5)Kravchenko, J (5)Kulminski, Alexander (5)Christensen, Kaare (4)Stallard, Eric (4)Province, MA (3)Bolund, L (2)... View MoreDate Issued2011 (4)2013 (3)2014 (2)2015 (2)2010 (1)2012 (1)2016 (1)2017 (1)Type
    Journal article (15)
    Subject
    Aged, 80 and over (15)
    Female (15)Humans (15)Male (15)Aged (13)Age Factors (7)Aging (7)Cohort Studies (6)Middle Aged (6)United States (6)... View MoreAffiliation of Duke Author(s)Center for Population Health & Aging (15)Duke (15)Duke Cancer Institute (15)Duke Population Research Center (15)Duke Population Research Institute (15)Institutes and Centers (15)Institutes and Provost's Academic Units (15)Sanford School of Public Policy (15)School of Medicine (15)Social Science Research Institute (15)... View More