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Recovery and survival from aging-associated diseases.
(Exp Gerontol, 2013-08)
OBJECTIVES: Considering disease incidence to be a main contributor to healthy lifespan
of the US elderly population may lead to erroneous conclusions when recovery/long-term
remission factors are underestimated. Using two ...
Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.
(Mech Ageing Dev, 2011-04)
Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring
of older fathers. Longer telomeres might increase cancer risk. We examined the relation
of father's age at the birth of the offspring ...
Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.
(Rejuvenation Res, 2016-06)
On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity
Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that
interactions between carrying FOXO1A-209 genotypes ...
GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.
(J Gerontol A Biol Sci Med Sci, 2015-04)
Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+
demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292
and tea drinking at around age 60 or at present time ...
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.
(Rejuvenation Res, 2015-04)
The lack of evolutionary established mechanisms linking genes to age-related traits
makes the problem of genetic susceptibility to health span inherently complex. One
complicating factor is genetic trade-off. Here we focused ...
Medical cost trajectories and onsets of cancer and noncancer diseases in US elderly population.
(Comput Math Methods Med, 2011)
Time trajectories of medical costs-associated with onset of twelve aging-related cancer
and chronic noncancer diseases were analyzed using the National Long-Term Care Survey
data linked to Medicare Service Use files. A special ...
Cardiovascular comorbidities and survival of lung cancer patients: Medicare data based analysis.
(Lung Cancer, 2017-06-05)
OBJECTIVES: To evaluate the role of cardiovascular disease (CVD) comorbidity in survival
of patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: The impact
of seven CVDs (at the time of NSCLC diagnosis ...
A new algorithm for predicting time to disease endpoints in Alzheimer's disease patients.
(J Alzheimers Dis, 2014)
BACKGROUND: The ability to predict the length of time to death and institutionalization
has strong implications for Alzheimer's disease patients and caregivers, health policy,
economics, and the design of intervention studies. ...
Health and function of participants in the Long Life Family Study: A comparison with other cohorts.
(Aging (Albany NY), 2011-01)
Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559)
were examined and compared to individuals from other cohorts to determine whether
the recruitment targeting longevity resulted in a cohort ...
Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.
(J Gerontol A Biol Sci Med Sci, 2013-07)
This study focuses on the participants of the Long Life Family Study to elucidate
whether biogenetic mechanisms underlying relationships among heritable complex phenotypes
in parents function in the same way for the same ...