Now showing items 1-10 of 906
Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton.
Autophagy has been predominantly studied as a nonselective self-digestion process that recycles macromolecules and produces energy in response to starvation. However, autophagy independent of nutrient status has long been ...
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
VCP (VCP/p97) is a ubiquitously expressed member of the AAA(+)-ATPase family of chaperone-like proteins that regulates numerous cellular processes including chromatin decondensation, homotypic membrane fusion and ...
Characterization of topographical effects on macrophage behavior in a foreign body response model.
Current strategies to limit macrophage adhesion, fusion and fibrous capsule formation in the foreign body response have focused on modulating material surface properties. We hypothesize that topography close to biological ...
Algal blooms and the nitrogen-enrichment hypothesis in Florida springs: evidence, alternatives, and adaptive management.
(Ecol Appl, 2010-04)
Contradictions between system-specific evidence and broader paradigms to explain ecosystem behavior present a challenge for natural resource management. In Florida (U.S.A.) springs, increasing nitrate (NO3-) concentrations ...
Critical role of TNF-α in cerebral aneurysm formation and progression to rupture.
(J Neuroinflammation, 2014-04-16)
BACKGROUND: Alterations in TNF-α expression have been associated with cerebral aneurysms, but a direct role in formation, progression, and rupture has not been established. METHODS: Cerebral aneurysms were induced through ...
Kinesins at a glance.
(J Cell Sci, 2010-10-15)
Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.
(PLoS One, 2015)
Addition of menthol to cigarettes may be associated with increased initiation of smoking. The potential mechanisms underlying this association are not known. Menthol, likely due to its effects on cold-sensing peripheral ...
Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions.
(PLoS One, 2010-09-09)
BACKGROUND: Isometric muscle contraction, where force is generated without muscle shortening, is a molecular traffic jam in which the number of actin-attached motors is maximized and all states of motor action are trapped ...
Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice.
(PLoS One, 2010-08-17)
BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation of immune responses against resident intestinal bacteria within a genetically susceptible host. Mast cells may play a critical role ...
Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.
(PLoS One, 2008-05-07)
BACKGROUND: Myosin VIIA (MyoVIIA) is an unconventional myosin necessary for vertebrate audition -. Human auditory transduction occurs in sensory hair cells with a staircase-like arrangement of apical protrusions called ...