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Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.

Inglese, J; Iñiguez-Lluhi, JA; Koch, Walter J; Lefkowitz, Robert J; Luttrell, LM; Touhara, K (Proc Natl Acad Sci U S A, 1994-04-26)

The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated receptor substrates, such as the beta-adrenergic receptor, triggering events leading to receptor desensitization. beta ARK activity is ...

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.

Akhter, SA; Avdonin, P; Cheng, H; Eschenhagen, T; Koch, Walter J; Lakatta, EG; Lefkowitz, Robert J; ... (9 authors) (Circ Res, 1999-01-08)

-Transgenic mouse models have been developed to manipulate beta-adrenergic receptor (betaAR) signal transduction. Although several of these models have altered betaAR subtypes, the specific functional sequelae of betaAR ...