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Hetahelical receptor signaling: Beyond the G protein paradigm
(Journal of Cell Biology, 1999-05-31)
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
(Proc Natl Acad Sci U S A, 1996-09-03)
Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled
receptor kinase-5 (GRK5), a serine/threonine kinase most abundantly expressed in the
heart compared with other tissues. Animals ...
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
(Proc Natl Acad Sci U S A, 1997-10-28)
Cardiovascular gene therapy is a novel approach to the treatment of diseases such
as congestive heart failure (CHF). Gene transfer to the heart would allow for the
replacement of defective or missing cellular proteins that ...
Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.
(Proc Natl Acad Sci U S A, 1993-04-15)
The physiological significance of multiple G-protein-coupled receptor subtypes, such
as the beta-adrenergic receptors (beta ARs), remains obscure, since in many cases
several subtypes activate the same effector and utilize ...
Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
(Proc Natl Acad Sci U S A, 1997-01-07)
Transgenic overexpression (40- to 100-fold) of the wild-type human beta2-adrenergic
receptor in the hearts of mice leads to a marked increase in cardiac contractility,
which is apparently due to the low level of spontaneous ...
Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
(Proc Natl Acad Sci U S A, 1996-07-23)
Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases
(GRKs) constitute a family of serine/threonine kinases that play a major role in the
agonist-induced phosphorylation and desensitization ...
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
(J Clin Invest, 1996-04-01)
To assess the effect of targeted myocardial beta-adrenergic receptor (AR) stimulation
on relaxation and phospholamban regulation, we studied the physiological and biochemical
alterations associated with overexpression of ...
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
(Proc Natl Acad Sci U S A, 1998-07-21)
The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic
receptor and plays a role in adrenergic regulation of Na+/H+ exchange. NHERF contains
two PDZ domains, the first of which is required ...
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
(Proc Natl Acad Sci U S A, 1994-10-11)
Transgenic mice were generated by using the alpha-myosin heavy chain promoter coupled
to the coding sequence of a constitutively active mutant alpha 1B-adrenergic receptor
(AR). These transgenic animals demonstrated ...
Diseased G protein-coupled receptors.
(J Clin Invest, 1993-11)