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Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
(Circ Res, 1999-11-26)
Cardiac beta(2)-adrenergic receptor (beta(2)AR) overexpression is a potential contractile
therapy for heart failure. Cardiac contractility was elevated in mice overexpressing
beta(2)ARs (TG4s) with no adverse effects under ...
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
(J Clin Invest, 1999-07)
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic
strategy for treatment of cardiovascular diseases such as heart failure (HF). Before
gene therapy approaches to alter cardiac function ...
A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.
(Proc Natl Acad Sci U S A, 1994-03-29)
The beta 2-adrenergic receptor (beta 2AR) can be constitutively activated by mutations
in the third intracellular loop. Whereas the wild-type receptor exists predominantly
in an inactive conformation (R) in the absence of ...
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
(Proc Natl Acad Sci U S A, 1994-04-26)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated
receptor substrates, such as the beta-adrenergic receptor, triggering events leading
to receptor desensitization. beta ARK activity is ...
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
(Proc Natl Acad Sci U S A, 1997-10-28)
Cardiovascular gene therapy is a novel approach to the treatment of diseases such
as congestive heart failure (CHF). Gene transfer to the heart would allow for the
replacement of defective or missing cellular proteins that ...
G proteins in medicine.
(N Engl J Med, 1995-01-19)
Adrenergic receptors. Models for regulation of signal transduction processes.
(Hypertension, 1990-02)
Adrenergic receptors are prototypic models for the study of the relations between
structure and function of G protein-coupled receptors. Each receptor is encoded by
a distinct gene. These receptors are integral membrane ...
A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.
(Proc Natl Acad Sci U S A, 1993-02-15)
We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase,
protein kinase C) in the olfactory system are essential in terminating second-messenger
signaling in response to odorants. We now document ...
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
(Proc Natl Acad Sci U S A, 1994-12-20)
Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein
kinases (MAP kinases). In several cell types, this appears to be dependent on the
activation of p21ras (Ras). Which G-protein subunit(s) ...