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Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
(Hypertension, 1999-01)
Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic
receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1,
which phosphorylates and desensitizes beta-adrenergic ...
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
(Arterioscler Thromb Vasc Biol, 1998-08)
Vein grafting results in the development of intimal hyperplasia with accompanying
changes in guanine nucleotide-binding (G) protein expression and function. Several
serum mitogens that act through G protein-coupled receptors, ...
Adrenergic receptors. Models for regulation of signal transduction processes.
(Hypertension, 1990-02)
Adrenergic receptors are prototypic models for the study of the relations between
structure and function of G protein-coupled receptors. Each receptor is encoded by
a distinct gene. These receptors are integral membrane ...
Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.
(Proc Natl Acad Sci U S A, 1992-07-01)
A number of lines of evidence suggest that cross-talk exists between the cellular
signal transduction pathways involving tyrosine phosphorylation catalyzed by members
of the pp60c-src kinase family and those mediated by ...
An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.
(Proc Natl Acad Sci U S A, 1994-04-26)
Phosphorylation of GTP-binding-regulatory (G)-protein-coupled receptors by specific
G-protein-coupled receptor kinases (GRKs) is a major mechanism responsible for agonist-mediated
desensitization of signal transduction processes. ...
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
(J Clin Invest, 1999-07)
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic
strategy for treatment of cardiovascular diseases such as heart failure (HF). Before
gene therapy approaches to alter cardiac function ...
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
(Proc Natl Acad Sci U S A, 1997-10-28)
Cardiovascular gene therapy is a novel approach to the treatment of diseases such
as congestive heart failure (CHF). Gene transfer to the heart would allow for the
replacement of defective or missing cellular proteins that ...
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
(J Clin Invest, 1997-01-15)
Our laboratory has been testing the hypothesis that genetic modulation of the beta-adrenergic
signaling cascade can enhance cardiac function. We have previously shown that transgenic
mice with cardiac overexpression of either ...
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
(Circulation, 1998-10-27)
BACKGROUND: Impaired myocardial beta-adrenergic receptor (betaAR) signaling, including
desensitization and functional uncoupling, is a characteristic of congestive heart
failure. A contributing mechanism for this impairment ...