Now showing items 1-10 of 29
Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report.
(Emerging infectious diseases, 1998-04)
Well-documented cases of simultaneous human infection with more than one tick-borne pathogen are rare. To our knowledge only two dual infections have been reported: simultaneous human infection with the agent of ...
Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.
(Proc Natl Acad Sci U S A, 1990-07)
Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the receptor away from the cell surface as well as a down-regulation ...
Chromosomal organization of adrenergic receptor genes.
(Proc Natl Acad Sci U S A, 1990-02)
The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone ...
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.
(Proc Natl Acad Sci U S A, 1990-07)
Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of multiple alpha 2-adrenergic receptor (alpha 2AR) subtypes. We have cloned a human alpha 2AR by using the polymerase chain reaction with ...
An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.
(Proc Natl Acad Sci U S A, 1994-04-26)
Phosphorylation of GTP-binding-regulatory (G)-protein-coupled receptors by specific G-protein-coupled receptor kinases (GRKs) is a major mechanism responsible for agonist-mediated desensitization of signal transduction processes. ...
Tobacco smoking and depressed mood in late childhood and early adolescence.
(American journal of public health, 1999-12)
OBJECTIVES:This study builds on previous observations about a suspected causal association linking tobacco smoking with depression. With prospective data, the study sheds new light on the temporal sequencing of tobacco smoking ...
Influence of comorbid alcohol and psychiatric disorders on utilization of mental health services in the National Comorbidity Survey.
(The American journal of psychiatry, 1999-08)
OBJECTIVE: This study sought to determine how comorbidity of psychiatric and substance abuse disorders affects the likelihood of using mental health services. METHOD: The analysis was based on data on adults aged 18-54 years ...
Panic attacks and suicide attempts in mid-adolescence.
(The American journal of psychiatry, 1999-10)
OBJECTIVE: The aim of this study was to investigate the association of panic attacks and suicide attempts in a community-based sample of 13-14-year-old adolescents. METHOD: The data are from a survey of 1,580 students in ...
Tobacco smoking and other suspected antecedents of nonmedical psychostimulant use in the United States, 1995.
(Substance use & misuse, 1999-07)
This study investigates the extent to which tobacco smoking is associated with the nonmedical use of psychostimulants and the temporal order of the age of first use for tobacco and psychostimulants within a nationally ...