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Cloning of the cDNA for the human beta 1-adrenergic receptor. 

Frielle, T; Collins, S; Daniel, KW; Caron, MG; Lefkowitz, RJ; Kobilka, BK (Proc Natl Acad Sci U S A, 1987-11)
Screening of a human placenta lambda gt11 library has led to the isolation of the cDNA for the human beta 1-adrenergic receptor (beta 1AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains ...
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cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. 

Kobilka, BK; Dixon, RA; Frielle, T; Dohlman, HG; Bolanowski, MA; Sigal, IS; Yang-Feng, TL; ... (10 authors) (Proc Natl Acad Sci U S A, 1987-01)
We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor. The deduced amino acid sequence (413 residues) is that of a protein containing seven clusters of hydrophobic amino acids suggestive of ...
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Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. 

Regan, JW; Kobilka, TS; Yang-Feng, TL; Caron, MG; Lefkowitz, RJ; Kobilka, BK (Proc Natl Acad Sci U S A, 1988-09)
An alpha 2-adrenergic receptor subtype has been cloned from a human kidney cDNA library using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The deduced amino acid sequence resembles the human platelet ...
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Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. 

Frielle, T; Daniel, KW; Caron, MG; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1988-12)
The beta 1- and beta 2-adrenergic receptors are two structurally related, but pharmacologically distinguishable, receptor subtypes, both of which activate adenylyl cyclase in a catecholamine-dependent manner through the ...

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AuthorCaron, MG (4)Lefkowitz, RJ (4)Frielle, T (3)Kobilka, BK (3)Daniel, KW (2)Yang-Feng, TL (2)Bolanowski, MA (1)Collins, S (1)Dixon, RA (1)Dohlman, HG (1)... View MoreDate Issued1987 (2)1988 (2)TypeJournal article (4)Subject
Amino Acid Sequence (4)
DNA (4)Humans (4)Animals (3)Base Sequence (3)Molecular Sequence Data (3)Protein Conformation (3)Receptors, Adrenergic, beta (3)Models, Molecular (2)Cell Line (1)... View MoreAffiliation of Duke Author(s)
Basic Science Departments (4)
Biochemistry (4)Cell Biology (4)Chemistry (4)Clinical Science Departments (4)Duke (4)Duke Cancer Institute (4)Duke Institute for Brain Sciences (4)Institutes and Centers (4)
Institutes and Provost's Academic Units (4)
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