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Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.
(PloS one, 2017-01)
Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage
matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum
levels of type IIA procollagen amino terminal propeptide ...
Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study.
(Nutrients, 2018-04-09)
Although dietary patterns are crucial to cognitive function, associations of dietary
patterns with cognitive function have not yet been fully understood. This cross-sectional
study explored dietary patterns associated with ...
Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change.
(BMC musculoskeletal disorders, 2016-11-10)
To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional
features observed in cases and controls, to define change over time for different
MRI features, and to report the extent of changes ...
Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?
(BMC musculoskeletal disorders, 2014-09-27)
Chondroitin Sulphate (CS), a natural glycosaminoglycan of the extracellular matrix,
has clinical benefit in symptomatic osteoarthritis but has never been tested in gout.
In vitro, CS has anti-inflammatory and positive effects ...
Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study.
(BioMed research international, 2018-01)
Background:The majority of patients develop posttraumatic osteoarthritis within 15
years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative
biomarkers have been associated with both pain and ...
Elucidating the Molecular Composition of Cartilage by Proteomics.
(J Proteome Res, 2016-02-05)
Articular cartilage consists of chondrocytes and two major components, a collagen-rich
framework and highly abundant proteoglycans. Most prior studies defining the zonal
distribution of cartilage have extracted proteins ...
A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)
BACKGROUND: The goal of many proteomics experiments is to determine the abundance
of proteins in biological samples, and the variation thereof in various physiological
conditions. High-throughput quantitative proteomics, ...
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)
BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our
objective was to explore the relationships of GlycA, a measure of glycosylated acute
phase proteins, with inflammation and cardiometabolic ...
The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis.
(Arthritis Res Ther, 2015-12-15)
BACKGROUND: In recent decades, low-level laser therapy (LLLT) has been widely used
to relieve pain caused by different musculoskeletal disorders. Though widely used,
its reported therapeutic outcomes are varied and conflicting. ...
Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?
(BMC Musculoskelet Disord, 2014-09-27)
BACKGROUND: Chondroitin Sulphate (CS), a natural glycosaminoglycan of the extracellular
matrix, has clinical benefit in symptomatic osteoarthritis but has never been tested
in gout. In vitro, CS has anti-inflammatory and ...