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Regulation of Chromosome Structure During Both of the Endocycle and Mitosis is Critical for Accurate Chromosome Segregation in Polypoid Mitosis 

Stormo, Benjamin (2017)
Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling cells undergo multiple rounds of genome duplication without an intervening mitosis. Endocycling is known to lead to alterations ...
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Integrative Analysis of the Genomics of the Human Glucocorticoid Response 

McDowell, Ian Christopher (2017)
Glucocorticoids (GCs) are potent steroid hormones that regulate immunity and metabolism, and do so primarily by activating the transcription factor glucocorticoid receptor (GR). Once activated, GR binds to thousands ...
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Basement  Membrane  Dynamics  During  Anchor  Cell  Invasion 

Morrissey, Meghan Ann (2015)
Basement membranes are a dense, sheet-like form of extracellular matrix that underlie epithelia and endothelia, and surround muscle, fat and Schwann cells. Basement membranes separate tissues and protect them from mechanical ...
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Genetic Analysis of Mitotic Recombination in Saccharomyces cerevisiae 

O'Connell, Karen Eileen (2016)
Mitotic genome instability can occur during the repair of double-strand breaks (DSBs) in DNA, which arise from endogenous and exogenous sources. Studying the mechanisms of DNA repair in the budding yeast, Saccharomyces cerevisiae ...
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The Discovery of EJC Independent Roles for EIF4A3 in Mitosis, Microtubules, and Neural Crest Development 

Miller, Emily Elizabeth (2017)
The exon junction complex (EJC) is comprised of three core components: MAGOH, RBM8A, and EIF4A3. The EJC is canonically known to regulate many aspects of RNA metabolism as well as function in mitosis. Previous work on the ...
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Mechanisms of Chlamydia manipulation of host cell biology revealed through genetic approaches 

Kokes, Marcela (2015)
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and is the leading cause of preventable blindness worldwide. Chlamydia is particularly intriguing from the perspective of cell biology because ...
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Mechanisms of Dual-Targeting Arabidopsis HEMERA to the Chloroplasts and Nucleus 

Nevarez, Patrick Andrew (2016)
When a plant emerges from the soil, it faces a critical developmental transition from utilizing stored energy to grow rapidly toward the light, to developing chloroplasts and beginning photosynthesis. While it is known ...
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Interpreting Human Genetic Variation through Genomics and In Vivo Models 

Frangakis, Stephan (2016)
Improvements in genomic technology, both in the increased speed and reduced cost of sequencing, have expanded the appreciation of the abundance of human genetic variation. However the sheer amount of variation, as well as ...
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Identifying Novel Cardiomyopathy Genes Using Drosophila melanogaster 

Casad, Michelle (2012)
Traditional <italic>Drosophila</italic> hearts screens have focused on early patterning and development, and adult heart phenotypes have only recently been pursued due to difficulty in accurately measuring cardiac function ...
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A Genome-Wide RNAi Screen Identifies CDC-42 and GDI-1 as In Vivo Regulators of Invadopodia 

Lohmer, Lauren Renee Lilley (2015)
Basement membrane (BM) is a sheet-like extracellular matrix that underlies most tissues and acts as a barrier to invading cells. Many cell types, including immune cells, cells migrating during development and morphogenesis, ...
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AuthorAdkar, Shaunak (1)Brown, Hannah Elizabeth (1)Casad, Michelle (1)Chee, Mark Kuan Leng (1)Chen, Yu-tsung Shane (1)Cohen, Erez (1)Frangakis, Stephan (1)Johnson, Jayme M. (1)Kokes, Marcela (1)Lee, Teresa Ena (1)... View MoreDate Issued2012 (5)2015 (4)2016 (4)2017 (3)2014 (2)2018 (2)2019 (2)2020 (2)2013 (1)TypeDissertation (25)Subject
Cellular biology (25)
Genetics (25)
Molecular biology (5)Drosophila (4)Developmental biology (3)Biology (2)CRISPR (2)Microbiology (2)yeast (2)2-hydroxyglutarate (1)... View MoreDepartmentGenetics and Genomics (8)Cell Biology (6)Molecular Genetics and Microbiology (4)Biology (3)Pathology (2)Biochemistry (1)Computational Biology and Bioinformatics (1)
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