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Regulation of Chromosome Structure During Both of the Endocycle and Mitosis is Critical for Accurate Chromosome Segregation in Polypoid Mitosis
(2017)
Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling
cells undergo multiple rounds of genome duplication without an intervening mitosis.
Endocycling is known to lead to alterations ...
Integrative Analysis of the Genomics of the Human Glucocorticoid Response
(2017)
Glucocorticoids (GCs) are potent steroid hormones that regulate immunity and metabolism,
and do so primarily by activating the transcription factor glucocorticoid receptor
(GR). Once activated, GR binds to thousands ...
Basement Membrane Dynamics During Anchor Cell Invasion
(2015)
Basement membranes are a dense, sheet-like form of extracellular matrix that underlie
epithelia and endothelia, and surround muscle, fat and Schwann cells. Basement membranes
separate tissues and protect them from mechanical ...
Genetic Analysis of Mitotic Recombination in Saccharomyces cerevisiae
(2016)
Mitotic genome instability can occur during the repair of double-strand breaks (DSBs)
in DNA, which arise from endogenous and exogenous sources. Studying the mechanisms
of DNA repair in the budding yeast, Saccharomyces cerevisiae ...
The Discovery of EJC Independent Roles for EIF4A3 in Mitosis, Microtubules, and Neural Crest Development
(2017)
The exon junction complex (EJC) is comprised of three core components: MAGOH, RBM8A,
and EIF4A3. The EJC is canonically known to regulate many aspects of RNA metabolism
as well as function in mitosis. Previous work on the ...
Mechanisms of Chlamydia manipulation of host cell biology revealed through genetic approaches
(2015)
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and
is the leading cause of preventable blindness worldwide. Chlamydia is particularly
intriguing from the perspective of cell biology because ...
Mechanisms of Dual-Targeting Arabidopsis HEMERA to the Chloroplasts and Nucleus
(2016)
When a plant emerges from the soil, it faces a critical developmental transition from
utilizing stored energy to grow rapidly toward the light, to developing chloroplasts
and beginning photosynthesis. While it is known ...
Interpreting Human Genetic Variation through Genomics and In Vivo Models
(2016)
Improvements in genomic technology, both in the increased speed and reduced cost of
sequencing, have expanded the appreciation of the abundance of human genetic variation.
However the sheer amount of variation, as well as ...
Identifying Novel Cardiomyopathy Genes Using Drosophila melanogaster
(2012)
Traditional <italic>Drosophila</italic> hearts screens have focused on early patterning
and development, and adult heart phenotypes have only recently been pursued due to
difficulty in accurately measuring cardiac function ...
A Genome-Wide RNAi Screen Identifies CDC-42 and GDI-1 as In Vivo Regulators of Invadopodia
(2015)
Basement membrane (BM) is a sheet-like extracellular matrix that underlies most tissues
and acts as a barrier to invading cells. Many cell types, including immune cells,
cells migrating during development and morphogenesis, ...