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Large-scale Effectors of Gene Expression and New Models of Cell Division in the Haloarchaea.
(2015)
Like most Archaea, the hypersaline-adapted organism Halobacterium salinarum exhibits
characteristics from all three domains of life, including a eukaryotic histone protein,
a universal propensity to genetic rearrangements, ...
Mechanisms of Chlamydia manipulation of host cell biology revealed through genetic approaches
(2015)
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and
is the leading cause of preventable blindness worldwide. Chlamydia is particularly
intriguing from the perspective of cell biology because ...
Genomic, Genetic, and Functional Interrogation of Mycobacterium tuberculosis Outbreak Strains
(2017)
In the past 200 years, tuberculosis (TB) has caused more deaths than any other infectious
disease and currently infects more people than it has at any other time in human history.
Mycobacterium tuberculosis (Mtb), the etiological ...
Genome evolution in the fungal pathogen Cryptococcus deuterogattii
(2017)
One of the key challenges of the 21st century is the emergence and reemergence of
pathogens. Fungal pathogens represent an important portion of this problem, as the
cohort of immunocompromised patients susceptible to common ...
Mechanisms of Protein Localization in Cryptococcus neoformans Mediate Virulence and Immune Recognition
(2018)
Cryptococcus neoformans is an opportunistic fungal pathogen that causes significant
disease and death in immunocompromised populations, in particular among those with
advanced HIV infection. This fungus is found ubiquitously ...
Examination of the Molecular Epidemiology, Expansion, Population Structure, and Virulence of the Emerging Fungal Pathogen,<italic>Cryptococcus gattii</italic> in the United States
(2010)
<italic>Cryptococcus gattii</italic> has been actively emerging and adapting to the
climates and environment in western North America, bringing with it life-threatening
disease to humans and animals. Through systematic ...
Bayesian modeling of microbial physiology
(2017)
Microbial population growth measurements are widespread in the study of microorganisms,
providing insight into areas including genetics, physiology, and engineering. The
most common models of microbial population growth ...
Using Single-Cell Analyses to Uncover Transcriptional Heterogeneity in Plasmodium falciparum
(2018)
Malaria persists as a global health problem, with 212 million cases and 429,000 deaths
worldwide in 2015 alone. It is caused by the apicomplexan parasite Plasmodium, which
follows a complex life cycle that consists of multiple ...
Diversity of Species and Sexual Reproduction in the Fungal Genus Cryptococcus
(2019)
Speciation is a central mechanism of biological diversification. While speciation
is well studied in plants and animals, in comparison, relatively little is known about
speciation in fungi. One fungal model is the Cryptococcus ...
Mechanisms of CD8+ T Cell Mediated Virus Inhibition in HIV-1 Virus Controllers
(2014)
CD8+ T cells are associated with long term control of virus replication to low or
undetectable levels in a population of HIV+ therapy-naïve individuals known as virus
controllers (VCs; <5000 RNA copies/ml and CD4+ lymphocyte ...