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Mechanisms of CD8+ T Cell Mediated Virus Inhibition in HIV-1 Virus Controllers
CD8+ T cells are associated with long term control of virus replication to low or undetectable levels in a population of HIV+ therapy-naïve individuals known as virus controllers (VCs; <5000 RNA copies/ml and CD4+ lymphocyte ...
Involvement of a DNA Polymerase III Subunit in the Bacterial Response to Quinolones
Quinolone treatment induces stabilized cleavage complexes (SCCs), consisting of a covalent gyrase-DNA complex, and processing of these complexes is thought to cause double-strand breaks and chromosome fragmentation. SCCs ...