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Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators
(2017)
Biological systems are highly dynamic, yet our temporal resolution of suchdynamical
processes is often limited or difficult to test in the laboratory. The 24-hourcircadian
rhythm and the approximately 75-minute cell cycle ...
Functional Interrogation Of Anti-Cancer Drug Resistance
(2017)
Targeted therapeutics are among the most promising approaches for treating diverse
forms of malignancies. Indeed, as sequencing prices and technology continue to improve
it will be possible to achieve a precise map of each ...
Genetic Constraints and the Evolution of Chemical Defenses in Multiple Tissues of Boechera stricta
(2017)
In order to deter herbivores, plants evolve defenses suited to different tissues and
varying patterns of herbivory. If the defense profiles of different tissues share
common genetic controls but differ in selective pressures, ...
Regulation of Chromosome Structure During Both of the Endocycle and Mitosis is Critical for Accurate Chromosome Segregation in Polypoid Mitosis
(2017)
Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling
cells undergo multiple rounds of genome duplication without an intervening mitosis.
Endocycling is known to lead to alterations ...
Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences
(2018)
Telomeric sequences are often located internally on the chromosome in addition to
their usual positions at the ends of the chromosome. These internally-located telomeric
sequences have been termed “interstitial telomeric ...
Integrative Analysis of the Genomics of the Human Glucocorticoid Response
(2017)
Glucocorticoids (GCs) are potent steroid hormones that regulate immunity and metabolism,
and do so primarily by activating the transcription factor glucocorticoid receptor
(GR). Once activated, GR binds to thousands ...
The Glucocorticoid-Mediated Dynamics of Genome Architecture
(2018)
Human cells are perpetually receiving and responding to a variety of intrinsic and
extrinsic signals. A primary mechanism by which cells carry out these responses is
via changes in the regulation of gene expression. Many ...
Using Genomic Tools to Understand Speciation Dynamics in Madagascar's Mouse Lemurs (Order: Primates)
(2019)
Mouse lemurs (genus Microcebus; Order Primates) are endemic to the island nation of
Madagascar. These small, nocturnal primates offer a unique mammalian system ideally
suited to study the patterns and processes of speciation, ...
Developmental Regulation in Response to Nutritional Status in Caenorhabditis elegans
(2019)
Developmental physiology is very sensitive to nutrient availability. For instance,
in the nematode C. elegans, newly hatched L1-stage larvae require food to initiate
postembryonic development. Despite the essential role ...
How Linkage Disequilibrium and Recombination Shape Genetic Variation Within and Between Species
(2019)
Meiotic recombination creates genetic diversity by shuffling combinations of alleles
across loci, yet alleles at neighboring loci often remain non-randomly associated.
This non-random association is known as linkage-dise...