Biological systems are highly dynamic, yet our temporal resolution of suchdynamical processes is often limited or difficult to test in the laboratory. The 24-hourcircadian rhythm and the approximately 75-minute cell cycle ...

Targeted therapeutics are among the most promising approaches for treating diverse forms of malignancies. Indeed, as sequencing prices and technology continue to improve it will be possible to achieve a precise map of each ...

In order to deter herbivores, plants evolve defenses suited to different tissues and varying patterns of herbivory. If the defense profiles of different tissues share common genetic controls but differ in selective pressures, ...

Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling cells undergo multiple rounds of genome duplication without an intervening mitosis. Endocycling is known to lead to alterations ...

Telomeric sequences are often located internally on the chromosome in addition to their usual positions at the ends of the chromosome. These internally-located telomeric sequences have been termed “interstitial telomeric ...

Glucocorticoids (GCs) are potent steroid hormones that regulate immunity and metabolism, and do so primarily by activating the transcription factor glucocorticoid receptor (GR). Once activated, GR binds to thousands ...

Human cells are perpetually receiving and responding to a variety of intrinsic and extrinsic signals. A primary mechanism by which cells carry out these responses is via changes in the regulation of gene expression. Many ...

Mouse lemurs (genus Microcebus; Order Primates) are endemic to the island nation of Madagascar. These small, nocturnal primates offer a unique mammalian system ideally suited to study the patterns and processes of speciation, ...

Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode C. elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. Despite the essential role ...

Meiotic recombination creates genetic diversity by shuffling combinations of alleles across loci, yet alleles at neighboring loci often remain non-randomly associated. This non-random association is known as linkage-dise...