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Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators 

Kelliher, Christina Marie (2017)
Biological systems are highly dynamic, yet our temporal resolution of suchdynamical processes is often limited or difficult to test in the laboratory. The 24-hourcircadian rhythm and the approximately 75-minute cell cycle ...
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Functional Interrogation Of Anti-Cancer Drug Resistance 

Winter, Peter Saville (2017)
Targeted therapeutics are among the most promising approaches for treating diverse forms of malignancies. Indeed, as sequencing prices and technology continue to improve it will be possible to achieve a precise map of each ...
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Genetic Constraints and the Evolution of Chemical Defenses in Multiple Tissues of Boechera stricta 

Keith, Rose Aileen (2017)
In order to deter herbivores, plants evolve defenses suited to different tissues and varying patterns of herbivory. If the defense profiles of different tissues share common genetic controls but differ in selective pressures, ...
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Regulation of Chromosome Structure During Both of the Endocycle and Mitosis is Critical for Accurate Chromosome Segregation in Polypoid Mitosis 

Stormo, Benjamin (2017)
Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling cells undergo multiple rounds of genome duplication without an intervening mitosis. Endocycling is known to lead to alterations ...
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Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences 

Moore, Anthony R (2018)
Telomeric sequences are often located internally on the chromosome in addition to their usual positions at the ends of the chromosome. These internally-located telomeric sequences have been termed “interstitial telomeric ...
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Integrative Analysis of the Genomics of the Human Glucocorticoid Response 

McDowell, Ian Christopher (2017)
Glucocorticoids (GCs) are potent steroid hormones that regulate immunity and metabolism, and do so primarily by activating the transcription factor glucocorticoid receptor (GR). Once activated, GR binds to thousands ...
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The Glucocorticoid-Mediated Dynamics of Genome Architecture 

D'Ippolito, Anthony (2018)
Human cells are perpetually receiving and responding to a variety of intrinsic and extrinsic signals. A primary mechanism by which cells carry out these responses is via changes in the regulation of gene expression. Many ...
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Using Genomic Tools to Understand Speciation Dynamics in Madagascar's Mouse Lemurs (Order: Primates) 

Campbell, Christopher Ryan (2019)
Mouse lemurs (genus Microcebus; Order Primates) are endemic to the island nation of Madagascar. These small, nocturnal primates offer a unique mammalian system ideally suited to study the patterns and processes of speciation, ...
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Developmental Regulation in Response to Nutritional Status in Caenorhabditis elegans 

Kaplan, Rebecca Whitehurst (2019)
Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode C. elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. Despite the essential role ...
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How Linkage Disequilibrium and Recombination Shape Genetic Variation Within and Between Species 

Korunes, Katharine L (2019)
Meiotic recombination creates genetic diversity by shuffling combinations of alleles across loci, yet alleles at neighboring loci often remain non-randomly associated. This non-random association is known as linkage-dise...
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AuthorAcharya, Chaitanya Ramanuj (1)Adkar, Shaunak (1)Ahern, Perciliz Lumaban Tan (1)Anderson, Blair (1)Aydin, Selcan (1)Bae, Sena (1)Baldridge, Laryssa Leigh (1)Ballou, Elizabeth Ripley (1)Belsky, Jason Alan (1)Bernal, Autumn Joy (1)... View MoreDate Issued2010 - 2020 (205)2009 - 2009 (2)TypeDissertation (207)Subject
Genetics (207)
Biology (42)Molecular biology (39)Cellular biology (25)Bioinformatics (20)Evolution & development (18)Microbiology (18)Neurosciences (18)Developmental biology (11)Ecology (11)... View MoreDepartmentGenetics and Genomics (92)Biology (29)Molecular Genetics and Microbiology (27)Computational Biology and Bioinformatics (13)Cell Biology (9)Pharmacology (6)Ecology (5)Pathology (5)Neurobiology (4)Biochemistry (3)... View More
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