The goal of this dissertation is to develop multimodal light scattering techniques using optical coherence tomography (OCT) to improve clinical diagnosis. OCT is a non-invasive optical imaging technique that utilizes low ...

Hepatocellular carcinoma (HCC) lesions are often preceded by liver cirrhosis or Hepatitis C, and patients with these diagnoses are monitored every six months with an ultrasound screening. B-mode ultrasound is an ideal imaging ...

Coronary heart disease contributed to approximately one in four deaths in the United States in 2014, and is caused by a restriction of blood flow to myocardial tissue. Stress echocardiography is a clinical technique used ...

Cardiac arrhythmias such as atrial fibrillation and ventricular tachycardia are closely associated with microscopic fibrotic changes in cardiac structure that result in a heterogeneous myocardium. While the incidence of ...

X-ray computed tomography (CT) is one of the most useful diagnostic tools for clinicians, with widespread availability, fast scan times, and low cost. CT imaging can reveal a patient’s anatomy in exquisite detail and is ...

Inferring brain states from EEG signals allows for the management of sleep disorders and brain diseases by providing an insight into the electrophysiological state of the brain. We explore the use of topic modeling – which ...

Traditionally, brain-machine interfaces (BMI) recorded from neurons in cerebralcortical regions associated with voluntary motor control including primary motor(M1), primary somatosensory (S1), and dorsal premotor (PMd) cortices. ...

Macrophages, key cells of the immune system, are often present at active sites of angiogenesis. It has been found that macrophages can play a critical role in supporting blood vessel development as the removal of these cells ...

The extracellular environment affects tissue structure and is a source of physical cues to guide cell behavior. The sensing and interpretation of physical cues is important in many physiological processes, such as tissue ...

The ability of tissue engineered constructs to replace diseased or damaged organs is limited without the incorporation of a functional vascular system. To design microvasculature that recapitulates the vascular niche functions ...