Now showing items 1-6 of 6
Synthesis of Protected Amines from Azadiene and Azaallyl Anion Building Blocks
Amines are ubiquitous in medicinal compounds and essential to human health. We have addressed the limitations of amine synthesis by significantly expanding the utility of 2-azaallyl anions and 2-azaallyl anion-like reagents ...
Towards Guiding Principles for Targeting RNA: Rational Approaches to Design and Synthesize RNA-Biased Small Molecule Libraries
RNA is increasingly recognized as a therapeutic target in many diseases, including viral and bacterial infections, neurodegenerative disease, and cancer. Despite this, no FDA-approved drugs target RNA, aside from select ...
Synthetic Studies toward Analogues of Manassantin A
In response to oxygen deprivation, tumor cells express a transcription factor, hypoxia inducible factor 1 (HIF-1). HIF-1 regulates the expression of genes involved in erythropoiesis, angiogenesis, and other adaptive responses ...
Zincative Functionalization of C–H Bonds Using Lithium Amide Zincate Bases
Carbon–hydrogen bond functionalization is a highly desirable transformation as C–H bonds are plentiful in feedstock chemicals and the direct introduction of valuable functional groups improves atom economy and efficiency. ...
Copper-Catalyzed Amino Oxygenation of Alkenes and Dienes: A Novel Amino-Initiation Pathway Using O-Benzoylhydroxylamines
Nitrogen-containing compounds, specifically the 1,2-oxyamino moiety, are of vital importance to modern pharmaceuticals, natural products, and agrochemicals. 1,2-Difunctionalization of alkenes offers an efficient approach ...
Chemical Biology Approaches to Combat Parkinson’s Disease
Parkinson's disease (PD) is a debilitating neurodegenerative disease of the central nervous system characterized by loss of striatal dopaminergic projections from the substantia nigra. Although there is no known cure for ...