Now showing items 1-6 of 6
Enzymatic Polymerization of High Molecular Weight DNA
The use of DNA as a polymeric building material transcends its function in biology and is exciting in bionanotechnology for applications ranging from biosensing, to diagnostics, and to targeted drug delivery. These applications ...
Magnetomicrofluidics Circuits for Organizing Bioparticle Arrays
Single-cell analysis (SCA) tools have important applications in the analysis of phenotypic heterogeneity, which is difficult or impossible to analyze in bulk cell culture or patient samples. SCA tools thus have a myriad ...
Model Membranes Study the Lipid-Reactivity of HIV-1 Antibodies and Vaccine Antigen
One promising HIV-1 vaccine target is the membrane-proximal external region (MPER) of viral gp41. MPER is poorly immunogenic, however, the two rare neutralizing antibodies (NAbs), 2F5 and 4E10, bind to MPER with ...
Adaptable Design Improvements For Electromagnetic Shock Wave Lithotripters And Techniques For Controlling Cavitation
In this dissertation work, the aim was to garner better mechanistic understanding of how shock wave lithotripsy (SWL) breaks stones in order to guide design improvements to a modern electromagnetic (EM) shock wave lithotripter. ...
Non-axisymmetric and Steerable Acoustic Field for Enhanced Stone Comminution in Shock Wave Lithotripsy
The primary goal of this dissertation was to assess the feasibility of transforming an electromagnetic (EM) shock wave lithotripter with an acoustic lens as its focusing device from the original axisymmetric pressure distribution ...
Design of Biomaterials toward Endogenous Skeletal Tissue Repair
Repair of skeletal tissues remains a significant challenge in patient care as there is high incidence of impaired fracture healing as well as irreversible cartilage degeneration following joint injury. To improve the repair ...