Now showing items 1-6 of 6
The role of H3.3K27M-induced gene repression in brainstem gliomagenesis
Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive pediatric brainstem tumor recently found to contain high incidence of H3.3K27M mutations. These mutations reprogram the H3K27me3 epigenetic landscape of DIPG ...
Transcriptional control of epidermal cell shape in the Drosophila embryo
During development, morphogenetic processes require the integration of numerous signals to properly shape cells and tissues. These signals are interpreted by cells to induce the precise transcriptional circuitry that controls ...
Next Gen sequencing tools to derive insights into protein expression and gene function
Human physiology is heavily influenced by the colonization of microbes in the gastrointestinal tract. A major roadblock to understanding this process is our inability to genetically manipulate new bacterial species ...
Population Sequencing for Studying Natural and Artifcial Variation in C. elegans
The advent of high coverage and low cost sequencing technologies has allowed fornewer and more powerful approaches in molecular and population genetics. Transposonsequencing, where genome-saturated mutant populations allele ...
Understanding the Effects of Genetic Variation on Osmo-adaptation Dynamics Across S. cerevisiae using Bulk Segregant Analysis and Whole Genome Sequencing
Adapting to environmental changes (i.e. an increase in osmolarity) is critical for cell survival. How cells respond and adapt to osmotic stress has been well-studied in the model eukaryote Saccharomyces cerevisiae. Although ...
Post-transcriptional Regulation of Cancer Traits and Gene Expression in a Genetically Defined, Primary Cell-derived Model of Breast Tumorigenesis
Post-transcriptional events are crucial determinants of gene expression, and aberrant expression patterns resulting from misregulation are evident in many pathological states. Cancer has traditionally been viewed as being ...