Direct carbon-carbon bond formation via soft enolization: aldol addition of alpha-halogenated thioesters

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2011

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Abstract

alpha-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr2 center dot OEt2 and i-Pr2NEt to produce alpha-halo-beta-hydroxy thioesters.

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Other article

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darzens, acids, triethylamine, 1,3-diketones, condensation, ketones, facile, esters, chemistry, multidisciplinary

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Yost,Julianne M.;Alfie,Rachel J.;Tarsis,Emily M.;Chong,Insun;Coltart,Don M.. 2011. Direct carbon-carbon bond formation via soft enolization: aldol addition of alpha-halogenated thioesters. Chemical Communications 47(1): 571-572.

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https://hdl.handle.net/10161/4130

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10.1039/c0cc02345k

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