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The impact of anxiety-inducing distraction on cognitive performance: a combined brain imaging and personality investigation.

dc.contributor.author Denkova, Ekaterina
dc.contributor.author Wong, Gloria
dc.contributor.author Dolcos, Sanda
dc.contributor.author Sung, Keen
dc.contributor.author Wang, Lihong
dc.contributor.author Coupland, Nicholas
dc.contributor.author Dolcos, Florin
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:32:20Z
dc.date.issued 2010-11-30
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21152391
dc.identifier.uri https://hdl.handle.net/10161/4585
dc.description.abstract BACKGROUND: Previous investigations revealed that the impact of task-irrelevant emotional distraction on ongoing goal-oriented cognitive processing is linked to opposite patterns of activation in emotional and perceptual vs. cognitive control/executive brain regions. However, little is known about the role of individual variations in these responses. The present study investigated the effect of trait anxiety on the neural responses mediating the impact of transient anxiety-inducing task-irrelevant distraction on cognitive performance, and on the neural correlates of coping with such distraction. We investigated whether activity in the brain regions sensitive to emotional distraction would show dissociable patterns of co-variation with measures indexing individual variations in trait anxiety and cognitive performance. METHODOLOGY/PRINCIPAL FINDINGS: Event-related fMRI data, recorded while healthy female participants performed a delayed-response working memory (WM) task with distraction, were investigated in conjunction with behavioural measures that assessed individual variations in both trait anxiety and WM performance. Consistent with increased sensitivity to emotional cues in high anxiety, specific perceptual areas (fusiform gyrus--FG) exhibited increased activity that was positively correlated with trait anxiety and negatively correlated with WM performance, whereas specific executive regions (right lateral prefrontal cortex--PFC) exhibited decreased activity that was negatively correlated with trait anxiety. The study also identified a role of the medial and left lateral PFC in coping with distraction, as opposed to reflecting a detrimental impact of emotional distraction. CONCLUSIONS: These findings provide initial evidence concerning the neural mechanisms sensitive to individual variations in trait anxiety and WM performance, which dissociate the detrimental impact of emotion distraction and the engagement of mechanisms to cope with distracting emotions. Our study sheds light on the neural correlates of emotion-cognition interactions in normal behaviour, which has implications for understanding factors that may influence susceptibility to affective disorders, in general, and to anxiety disorders, in particular.
dc.language eng
dc.language.iso en_US
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0014150
dc.subject Adolescent
dc.subject Adult
dc.subject Anxiety
dc.subject Anxiety Disorders
dc.subject Brain Mapping
dc.subject Cognition
dc.subject Emotions
dc.subject Female
dc.subject Humans
dc.subject Magnetic Resonance Imaging
dc.subject Personality
dc.subject Prefrontal Cortex
dc.subject Psychomotor Performance
dc.subject Task Performance and Analysis
dc.subject Young Adult
dc.title The impact of anxiety-inducing distraction on cognitive performance: a combined brain imaging and personality investigation.
dc.title.alternative
dc.type Journal article
duke.contributor.id Wang, Lihong|0290700
dc.description.version Version of Record
duke.date.pubdate 2010-11-30
duke.description.issue 11
duke.description.volume 5
dc.relation.journal Plos One
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21152391
pubs.begin-page e14150
pubs.issue 11
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke-UNC Center for Brain Imaging and Analysis
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203


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