Show simple item record Denkova, E Wong, G Dolcos, S Sung, K Wang, L Coupland, N Dolcos, F
dc.coverage.spatial United States 2011-06-21T17:32:20Z 2010-11-30
dc.identifier.citation PLoS One, 2010, 5 (11), pp. e14150 - ?
dc.description.abstract BACKGROUND: Previous investigations revealed that the impact of task-irrelevant emotional distraction on ongoing goal-oriented cognitive processing is linked to opposite patterns of activation in emotional and perceptual vs. cognitive control/executive brain regions. However, little is known about the role of individual variations in these responses. The present study investigated the effect of trait anxiety on the neural responses mediating the impact of transient anxiety-inducing task-irrelevant distraction on cognitive performance, and on the neural correlates of coping with such distraction. We investigated whether activity in the brain regions sensitive to emotional distraction would show dissociable patterns of co-variation with measures indexing individual variations in trait anxiety and cognitive performance. METHODOLOGY/PRINCIPAL FINDINGS: Event-related fMRI data, recorded while healthy female participants performed a delayed-response working memory (WM) task with distraction, were investigated in conjunction with behavioural measures that assessed individual variations in both trait anxiety and WM performance. Consistent with increased sensitivity to emotional cues in high anxiety, specific perceptual areas (fusiform gyrus--FG) exhibited increased activity that was positively correlated with trait anxiety and negatively correlated with WM performance, whereas specific executive regions (right lateral prefrontal cortex--PFC) exhibited decreased activity that was negatively correlated with trait anxiety. The study also identified a role of the medial and left lateral PFC in coping with distraction, as opposed to reflecting a detrimental impact of emotional distraction. CONCLUSIONS: These findings provide initial evidence concerning the neural mechanisms sensitive to individual variations in trait anxiety and WM performance, which dissociate the detrimental impact of emotion distraction and the engagement of mechanisms to cope with distracting emotions. Our study sheds light on the neural correlates of emotion-cognition interactions in normal behaviour, which has implications for understanding factors that may influence susceptibility to affective disorders, in general, and to anxiety disorders, in particular.
dc.format.extent e14150 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0014150
dc.subject Adolescent
dc.subject Adult
dc.subject Anxiety
dc.subject Anxiety Disorders
dc.subject Brain Mapping
dc.subject Cognition
dc.subject Emotions
dc.subject Female
dc.subject Humans
dc.subject Magnetic Resonance Imaging
dc.subject Personality
dc.subject Prefrontal Cortex
dc.subject Psychomotor Performance
dc.subject Task Performance and Analysis
dc.subject Young Adult
dc.title The impact of anxiety-inducing distraction on cognitive performance: a combined brain imaging and personality investigation.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-11-30 en_US
duke.description.endpage e14150 en_US
duke.description.issue 11 en_US
duke.description.startpage e14150 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US
pubs.issue 11
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences/Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke-UNC Center for Brain Imaging and Analysis
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203

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