Show simple item record Rudicell, RS Holland Jones, J Wroblewski, EE Learn, GH Li, Y Robertson, JD Greengrass, E Grossmann, F Kamenya, S Pintea, L Mjungu, DC Lonsdorf, EV Mosser, A Lehman, C Collins, DA Keele, BF Goodall, J Hahn, BH Pusey, AE Wilson, ML
dc.coverage.spatial United States 2011-06-21T17:32:23Z 2010-09-23
dc.identifier.citation PLoS Pathog, 2010, 6 (9), pp. e1001116 - ?
dc.description.abstract Like human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus of chimpanzees (SIVcpz) can cause CD4+ T cell loss and premature death. Here, we used molecular surveillance tools and mathematical modeling to estimate the impact of SIVcpz infection on chimpanzee population dynamics. Habituated (Mitumba and Kasekela) and non-habituated (Kalande) chimpanzees were studied in Gombe National Park, Tanzania. Ape population sizes were determined from demographic records (Mitumba and Kasekela) or individual sightings and genotyping (Kalande), while SIVcpz prevalence rates were monitored using non-invasive methods. Between 2002-2009, the Mitumba and Kasekela communities experienced mean annual growth rates of 1.9% and 2.4%, respectively, while Kalande chimpanzees suffered a significant decline, with a mean growth rate of -6.5% to -7.4%, depending on population estimates. A rapid decline in Kalande was first noted in the 1990s and originally attributed to poaching and reduced food sources. However, between 2002-2009, we found a mean SIVcpz prevalence in Kalande of 46.1%, which was almost four times higher than the prevalence in Mitumba (12.7%) and Kasekela (12.1%). To explore whether SIVcpz contributed to the Kalande decline, we used empirically determined SIVcpz transmission probabilities as well as chimpanzee mortality, mating and migration data to model the effect of viral pathogenicity on chimpanzee population growth. Deterministic calculations indicated that a prevalence of greater than 3.4% would result in negative growth and eventual population extinction, even using conservative mortality estimates. However, stochastic models revealed that in representative populations, SIVcpz, and not its host species, frequently went extinct. High SIVcpz transmission probability and excess mortality reduced population persistence, while intercommunity migration often rescued infected communities, even when immigrating females had a chance of being SIVcpz infected. Together, these results suggest that the decline of the Kalande community was caused, at least in part, by high levels of SIVcpz infection. However, population extinction is not an inevitable consequence of SIVcpz infection, but depends on additional variables, such as migration, that promote survival. These findings are consistent with the uneven distribution of SIVcpz throughout central Africa and explain how chimpanzees in Gombe and elsewhere can be at equipoise with this pathogen.
dc.format.extent e1001116 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS Pathog
dc.relation.isversionof 10.1371/journal.ppat.1001116
dc.subject Animals
dc.subject CD4-Positive T-Lymphocytes
dc.subject Computer Simulation
dc.subject Feces
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Models, Statistical
dc.subject Pan troglodytes
dc.subject Phylogeny
dc.subject Population Dynamics
dc.subject RNA, Messenger
dc.subject RNA, Viral
dc.subject Reverse Transcriptase Polymerase Chain Reaction
dc.subject Simian Acquired Immunodeficiency Syndrome
dc.subject Simian Immunodeficiency Virus
dc.subject Tanzania
dc.title Impact of simian immunodeficiency virus infection on chimpanzee population dynamics.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-9-0 en_US
duke.description.endpage e1001116 en_US
duke.description.issue 9 en_US
duke.description.startpage e1001116 en_US
duke.description.volume 6 en_US
dc.relation.journal Plos Pathogens en_US
pubs.issue 9
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Evolutionary Anthropology
pubs.publication-status Published online
pubs.volume 6
dc.identifier.eissn 1553-7374

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