Show simple item record Bohn, LM Gainetdinov, RR Sotnikova, TD Medvedev, IO Lefkowitz, RJ Dykstra, LA Caron, MG
dc.coverage.spatial United States 2012-10-24T20:17:06Z 2003-11-12
dc.identifier 23/32/10265
dc.identifier.citation J Neurosci, 2003, 23 (32), pp. 10265 - 10273
dc.description.abstract The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled receptor (GPCR) family of proteins. GPCRs are known to undergo desensitization involving phosphorylation of the receptor and the subsequent binding of beta(arrestins), which prevents further receptor-G-protein coupling. Mice lacking beta(arrestin)-2 (beta(arr2)) display enhanced sensitivity to morphine in tests of pain perception attributable to impaired desensitization of muOR. However, whether abrogating muOR desensitization affects the reinforcing and psychomotor properties of morphine has remained unexplored. In the present study, we examined this question by assessing the effects of morphine and cocaine on locomotor activity, behavioral sensitization, conditioned place preference, and striatal dopamine release in beta(arr2) knock-out (beta(arr2)-KO) mice and their wild-type (WT) controls. Cocaine treatment resulted in very similar neurochemical and behavioral responses between the genotypes. However, in the beta(arr2)-KO mice, morphine induced more pronounced increases in striatal extracellular dopamine than in WT mice. Moreover, the rewarding properties of morphine in the conditioned place preference test were greater in the beta(arr2)-KO mice when compared with the WT mice. Thus, beta(arr2) appears to play a more important role in the dopaminergic effects mediated by morphine than those induced by cocaine.
dc.format.extent 10265 - 10273
dc.language eng
dc.relation.ispartof J Neurosci
dc.subject Animals
dc.subject Arrestins
dc.subject Behavior, Animal
dc.subject Cocaine
dc.subject Corpus Striatum
dc.subject Dopamine
dc.subject Male
dc.subject Mice
dc.subject Mice, Knockout
dc.subject Microdialysis
dc.subject Morphine
dc.subject Motor Activity
dc.subject Reward
dc.subject Spatial Behavior
dc.subject beta-Arrestin 2
dc.subject beta-Arrestins
dc.title Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
dc.type Journal Article
duke.description.endpage 10273 en_US
duke.description.issue 32 en_US
duke.description.startpage 10265 en_US
duke.description.volume 23 en_US
dc.relation.journal Journal of Neuroscience en_US
pubs.issue 32
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Biochemistry
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Cell Biology
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Neurobiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Chemistry
pubs.publication-status Published
pubs.volume 23
dc.identifier.eissn 1529-2401

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