Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans.
Abstract
Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports
suggest that excess of nutrients involved in the one-carbon metabolism pathway increases
PC risk; however, empirical data are lacking. Veteran American men (272 controls and
144 PC cases) who attended the Durham Veteran American Medical Center between 2004-2009
were enrolled into a case-control study. Intake of folate, vitamin B12, B6, and methionine
were measured using a food frequency questionnaire. Regression models were used to
evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants,
and prostate cancer. Higher dietary methionine intake was associated with PC risk
(OR = 2.1; 95%CI 1.1-3.9) The risk was most pronounced in men with Gleason sum <7
(OR = 2.75; 95%CI 1.32- 5.73). The association of higher methionine intake and PC
risk was only apparent in men who carried at least one MTHFR A1298C allele (OR = 6.7;
95%CI = 1.6-27.8), compared to MTHFR A1298A noncarrier men (OR = 0.9; 95%CI = 0.24-3.92)
(p-interaction = 0.045). There was no evidence for associations between B vitamins
(folate, B12, and B6) and PC risk. Our results suggest that carrying the MTHFR A1298C
variants modifies the association between high methionine intake and PC risk. Larger
studies are required to validate these findings.
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https://hdl.handle.net/10161/6105Published Version (Please cite this version)
10.1155/2012/957467Publication Info
Vidal, Adriana C; Grant, Delores J; Williams, Christina D; Masko, Elizabeth; Allott,
Emma H; Shuler, Kathryn; ... Hoyo, Cathrine (2012). Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate
Cancer Risk in American Veterans. J Cancer Epidemiol, 2012. pp. 1-9. 10.1155/2012/957467. Retrieved from https://hdl.handle.net/10161/6105.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Jen-Tsan Ashley Chi
Associate Professor in Molecular Genetics and Microbiology
We are using functional genomic approaches to investigate the nutrient signaling and
stress adaptations of cancer cells when exposed to various nutrient deprivations and
microenvironmental stress conditions. Recently, we focus on two areas. First, we are
elucidating the genetic determinants and disease relevance of ferroptosis, a newly
recognized form of cell death. Second, we have identified the mammalian stringent
response pathway which is highly similar to bacterial stringent response, but
Leah Davis
Biostatistician II
Christina D Williams
Assistant Professor in Medicine
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