Quantum dot-based theranostics
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Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have advanced the fields of molecular diagnostics and nanotherapeutics. Much of the initial progress for QDs in biology and medicine has focused on developing new biosensing formats to push the limit of detection sensitivity. Nevertheless. QDs can be more than passive bio-probes or labels for biological imaging and cellular studies. The high surface-to-volume ratio of QDs enables the construction of a "smart" multifunctional nanoplatform, where the QDs serve not only as an imaging agent but also a nanoscaffold catering for therapeutic and diagnostic (theranostic) modalities. This mini review highlights the emerging applications of functionalized QDs as fluorescence contrast agents for imaging or as nanoscale vehicles for delivery of therapeutics, with special attention paid to the promise and challenges towards QD-based theranostics.
Subjectresonance energy-transfer in-vivo semiconductor nanocrystals gene delivery multifunctional nanoparticles intracellular delivery gold nanoparticles cellular uptake sirna delivery cancer-therapy
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Adjunct Professor of Biomedical Engineering
Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine Biomaterials Design: design of self-assembled fibers for tissue engineering microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery synthesis of novel quantum dots for biomedical applications Con