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Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

dc.contributor.author Cotecchia, S
dc.contributor.author Schwinn, DA
dc.contributor.author Randall, RR
dc.contributor.author Lefkowitz, RJ
dc.contributor.author Caron, MG
dc.contributor.author Kobilka, BK
dc.coverage.spatial United States
dc.date.accessioned 2013-09-24T17:43:59Z
dc.date.issued 1988-10
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/2845398
dc.identifier.issn 0027-8424
dc.identifier.uri https://hdl.handle.net/10161/7870
dc.description.abstract The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the receptor protein purified from DDT1MF-2 smooth muscle cells. The deduced amino acid sequence encodes a 515-residue polypeptide that shows the most sequence identity with the other adrenergic receptors and the putative protein product of the related clone G-21. Similarities with the muscarinic cholinergic receptors are also evident. Expression studies in COS-7 cells confirm that we have cloned the alpha 1-adrenergic receptor that couples to inositol phospholipid metabolism.
dc.language eng
dc.publisher Proceedings of the National Academy of Sciences
dc.relation.ispartof Proc Natl Acad Sci U S A
dc.subject Animals
dc.subject Base Sequence
dc.subject Cloning, Molecular
dc.subject Cricetinae
dc.subject DNA
dc.subject GTP-Binding Proteins
dc.subject Gene Expression Regulation
dc.subject Molecular Sequence Data
dc.subject Phosphatidylinositols
dc.subject Receptors, Adrenergic, alpha
dc.title Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
dc.type Journal article
duke.contributor.id Lefkowitz, RJ|0096962
duke.contributor.id Caron, MG|0112275
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/2845398
pubs.begin-page 7159
pubs.end-page 7163
pubs.issue 19
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biochemistry
pubs.organisational-group Cell Biology
pubs.organisational-group Chemistry
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group Neurobiology
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 85


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