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The influence of hepatic function on prostate cancer outcomes after radical prostatectomy.

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Date
2010-06
Authors
Bañez, LL
Loftis, RM
Freedland, SJ
Presti, JC
Aronson, WJ
Amling, CL
Kane, CJ
Terris, MK
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Abstract
Prostate growth is dependent on circulating androgens, which can be influenced by hepatic function. Liver disease has been suggested to influence prostate cancer (CaP) incidence. However, the effect of hepatic function on CaP outcomes has not been investigated. A total of 1181 patients who underwent radical prostatectomy (RP) between 1988 and 2008 at four Veterans Affairs hospitals that comprise the Shared Equal Access Regional Cancer Hospital database and had available liver function test (LFT) data were included in the study. Independent associations of LFTs with unfavorable pathological features and biochemical recurrence were determined using logistic and Cox regression analyses. Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were elevated in 8.2 and 4.4% of patients, respectively. After controlling for CaP features, logistic regression revealed a significant association between SGOT levels and pathological Gleason sum > or =7(4+3) cancer (odds ratio=2.12; 95% confidence interval=1.11-4.05; P=0.02). Mild hepatic dysfunction was significantly associated with adverse CaP grade, but was not significantly associated with other adverse pathological features or biochemical recurrence in a cohort of men undergoing RP. The effect of moderate-to-severe liver disease on disease outcomes in CaP patients managed non-surgically remains to be investigated.
Type
Journal article
Subject
Alanine Transaminase
Aspartate Aminotransferases
Humans
Liver
Liver Diseases
Liver Function Tests
Male
Middle Aged
Neoplasm Recurrence, Local
Prostatectomy
Prostatic Neoplasms
Risk
Treatment Outcome
Permalink
https://hdl.handle.net/10161/8619
Published Version (Please cite this version)
10.1038/pcan.2010.3
Publication Info
Bañez, LL; Loftis, RM; Freedland, SJ; Presti, JC; Aronson, WJ; Amling, CL; ... Terris, MK (2010). The influence of hepatic function on prostate cancer outcomes after radical prostatectomy. Prostate Cancer Prostatic Dis, 13(2). pp. 173-177. 10.1038/pcan.2010.3. Retrieved from https://hdl.handle.net/10161/8619.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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