The influence of hepatic function on prostate cancer outcomes after radical prostatectomy.
Abstract
Prostate growth is dependent on circulating androgens, which can be influenced by
hepatic function. Liver disease has been suggested to influence prostate cancer (CaP)
incidence. However, the effect of hepatic function on CaP outcomes has not been investigated.
A total of 1181 patients who underwent radical prostatectomy (RP) between 1988 and
2008 at four Veterans Affairs hospitals that comprise the Shared Equal Access Regional
Cancer Hospital database and had available liver function test (LFT) data were included
in the study. Independent associations of LFTs with unfavorable pathological features
and biochemical recurrence were determined using logistic and Cox regression analyses.
Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase
(SGPT) levels were elevated in 8.2 and 4.4% of patients, respectively. After controlling
for CaP features, logistic regression revealed a significant association between SGOT
levels and pathological Gleason sum > or =7(4+3) cancer (odds ratio=2.12; 95% confidence
interval=1.11-4.05; P=0.02). Mild hepatic dysfunction was significantly associated
with adverse CaP grade, but was not significantly associated with other adverse pathological
features or biochemical recurrence in a cohort of men undergoing RP. The effect of
moderate-to-severe liver disease on disease outcomes in CaP patients managed non-surgically
remains to be investigated.
Type
Journal articleSubject
Alanine TransaminaseAspartate Aminotransferases
Humans
Liver
Liver Diseases
Liver Function Tests
Male
Middle Aged
Neoplasm Recurrence, Local
Prostatectomy
Prostatic Neoplasms
Risk
Treatment Outcome
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https://hdl.handle.net/10161/8619Published Version (Please cite this version)
10.1038/pcan.2010.3Publication Info
Bañez, LL; Loftis, RM; Freedland, SJ; Presti, JC; Aronson, WJ; Amling, CL; ... Terris,
MK (2010). The influence of hepatic function on prostate cancer outcomes after radical prostatectomy.
Prostate Cancer Prostatic Dis, 13(2). pp. 173-177. 10.1038/pcan.2010.3. Retrieved from https://hdl.handle.net/10161/8619.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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