Thromboembolism and bleeding in bladder cancer.
Abstract
Bladder cancer is a unique disease process in that clinically significant hemorrhage
can occur simultaneously with equally significant aberrant clotting. With hematuria
the key presenting symptom of bladder cancer, hemorrhage is generally thought to be
a component of the natural history of the disease, and to commonly occur during its
treatment. However, as those who regularly treat bladder cancer know, the need to
address a predisposition to clotting is also very much part of the treatment paradigm.
Physicians must be cognizant of the biochemical changes that confer a propensity for
both significant bleeding and clotting occurring simultaneously in their patients.
Both of these entities remain important issues, and further study is needed to find
ways to mitigate and balance the associated risks. Here, we performed a review of
the literature, focusing on the concomitant issues of bleeding and venous thromboembolism
in both the pre- and post-operative periods in patients with bladder cancer. We formulated
a general management approach with respect to these two processes, and we provide
direction for further investigation.
Type
Journal articlePermalink
https://hdl.handle.net/10161/9377Collections
More Info
Show full item recordScholars@Duke
Brant Allen Inman
Professor of Surgery
Clinical research interests: Clinical trials of novel diagnostic tests and therapies
for genitourinary malignancies, with a strong focus on bladder cancer. Basic science
research interests: Immune therapies for cancer, hyperthermia and heat-based treatment
of cancer, molecular biology of genitourinary cancers, novel diagnostics and therapies
for genitourinary cancers

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info