Clinical applications of liquid biopsies in gastrointestinal oncology.

Loading...
Thumbnail Image

Date

2016-10

Journal Title

Journal ISSN

Volume Title

Citation Stats

Attention Stats

Abstract

"Liquid biopsies" are blood based assays used to detect and analyze circulating tumor products, including circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating messenger RNA (mRNA), circulating microRNA (miRNA), circulating exosomes, and tumor educated platelets (TEP). For patients with gastrointestinal (GI) malignancies, blood based biopsies may offer several advantages. First, tumor tissue samples are often challenging to procure, and when obtainable, are often insufficient for genomic profiling. Second, blood based assays offer a real-time overview of the entire tumor burden, and allow anatomically unbiased genomic profiling. Third, given the convenience and relative safety of liquid biopsies, this technology may facilitate identification of genomic alterations that confer sensitivity and resistance to targeted therapeutics. This review will assess the clinical applications of circulating tumor products for patients with GI tumors.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.21037/jgo.2016.08.08

Publication Info

Zhu, Jason, and John H Strickler (2016). Clinical applications of liquid biopsies in gastrointestinal oncology. Journal of gastrointestinal oncology, 7(5). pp. 675–686. 10.21037/jgo.2016.08.08 Retrieved from https://hdl.handle.net/10161/17205.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.

Scholars@Duke

Strickler

John Strickler

Professor of Medicine

Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.