A protocol to evaluate the efficacy, perceptions, and cost of a cholesterol packaging approach to improve medication adherence.
| dc.contributor.author | Zullig, Leah L | |
| dc.contributor.author | Pathman, Joshua | |
| dc.contributor.author | Melnyk, S Dee | |
| dc.contributor.author | Brown, Jamie N | |
| dc.contributor.author | Sanders, Linda L | |
| dc.contributor.author | Koropchak, Celine | |
| dc.contributor.author | Howard, Teresa | |
| dc.contributor.author | Danus, Susanne | |
| dc.contributor.author | McCant, Felicia | |
| dc.contributor.author | Bosworth, Hayden B | |
| dc.date.accessioned | 2024-02-01T15:57:49Z | |
| dc.date.available | 2024-02-01T15:57:49Z | |
| dc.date.issued | 2014-09 | |
| dc.description.abstract | PurposeElevated low-density lipoprotein cholesterol (LDL-C) is a major modifiable risk factor for cardiovascular disease (CVD), a leading cause of death in the United States. Despite clinical practice guidelines aimed at facilitating LDL-C control, many Veterans do not achieve guideline-recommended LDL-C levels.MethodsWe describe a study focused on VA healthcare system users at risk for CVD (i.e., LDL-C level >130 mg/dl and/or <80% cholesterol pill refill adherence in the last 12 months). We are conducting a two and a half year randomized controlled trial (i.e., intervention administered over 12 months) among Veterans with uncontrolled cholesterol receiving care at select VA-affiliated primary care clinics in North Carolina. We anticipate enrolling 250 diverse patients (10% women; 40% African American). Patients are randomized to an educational control group or intervention group. Intervention group participants' medication is provided in special blister packaging labeled for daily use that includes reminders; MeadWestvaco Corporation's pre-filled DosePakĀ® contains standard doses of statins in accordance with the existing prescriptions.ConclusionsPre-filled blister packaging may provide an inexpensive solution to improve medication adherence. Our study enrolls a diverse sample and provides information about whether an adherence packaging intervention can: 1) improve medication adherence; 2) improve patients' LDL-C levels; 3) be well received by patients and providers; and 4) provide a cost effective solution to improve medication adherence. | |
| dc.identifier | S1551-7144(14)00121-9 | |
| dc.identifier.issn | 1551-7144 | |
| dc.identifier.issn | 1559-2030 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Contemporary clinical trials | |
| dc.relation.isversionof | 10.1016/j.cct.2014.08.003 | |
| dc.rights.uri | ||
| dc.subject | Humans | |
| dc.subject | Cardiovascular Diseases | |
| dc.subject | Hypercholesterolemia | |
| dc.subject | Hydroxymethylglutaryl-CoA Reductase Inhibitors | |
| dc.subject | Risk Factors | |
| dc.subject | Drug Packaging | |
| dc.subject | Research Design | |
| dc.subject | United States Department of Veterans Affairs | |
| dc.subject | United States | |
| dc.subject | North Carolina | |
| dc.subject | Female | |
| dc.subject | Male | |
| dc.subject | Cholesterol, LDL | |
| dc.subject | Patient Education as Topic | |
| dc.subject | Medication Adherence | |
| dc.title | A protocol to evaluate the efficacy, perceptions, and cost of a cholesterol packaging approach to improve medication adherence. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Zullig, Leah L|0000-0002-6638-409X | |
| duke.contributor.orcid | Bosworth, Hayden B|0000-0001-6188-9825 | |
| pubs.begin-page | 106 | |
| pubs.end-page | 112 | |
| pubs.issue | 1 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Medicine, General Internal Medicine | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Duke Science & Society | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Duke Innovation & Entrepreneurship | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences | |
| pubs.organisational-group | Duke - Margolis Center For Health Policy | |
| pubs.publication-status | Published | |
| pubs.volume | 39 |
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