Relationship between neural functional connectivity and memory performance in age-related macular degeneration.
| dc.contributor.author | Zuo, Xintong | |
| dc.contributor.author | Zhuang, Jie | |
| dc.contributor.author | Chen, Nan-Kuei | |
| dc.contributor.author | Cousins, Scott | |
| dc.contributor.author | Cunha, Priscila | |
| dc.contributor.author | Lad, Eleonora M | |
| dc.contributor.author | Madden, David J | |
| dc.contributor.author | Potter, Guy | |
| dc.contributor.author | Whitson, Heather E | |
| dc.date.accessioned | 2021-04-03T13:55:36Z | |
| dc.date.available | 2021-04-03T13:55:36Z | |
| dc.date.issued | 2020-11 | |
| dc.date.updated | 2021-04-03T13:55:35Z | |
| dc.description.abstract | Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysis to quantify the strength of functional connectivity between hubs of the default mode network and a network of medial temporal regions relevant for memory. Our results indicated neither memory performance nor network connectivity differed by AMD status. However, the AMD participants exhibited stronger relationships than the controls between memory performance and connectivity from the memory network hub (left parahippocampal) to 2 other regions: the left temporal pole and the right superior/middle frontal gyri. Also, the connectivity between the medial prefrontal cortex and posterior cingulate cortex of default mode network correlated more strongly with memory performance in AMD compared to control. We concluded that stronger brain-behavior correlation in AMD may suggest a role for region-specific connectivity in supporting memory in the context of AMD. | |
| dc.identifier | S0197-4580(20)30237-2 | |
| dc.identifier.issn | 0197-4580 | |
| dc.identifier.issn | 1558-1497 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Neurobiology of aging | |
| dc.relation.isversionof | 10.1016/j.neurobiolaging.2020.07.020 | |
| dc.subject | AMD | |
| dc.subject | DMN | |
| dc.subject | Episodic memory | |
| dc.subject | LPHC | |
| dc.subject | Older adults | |
| dc.subject | Visual impairment | |
| dc.title | Relationship between neural functional connectivity and memory performance in age-related macular degeneration. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Madden, David J|0000-0003-2815-6552 | |
| duke.contributor.orcid | Whitson, Heather E|0000-0002-8417-4846 | |
| pubs.begin-page | 176 | |
| pubs.end-page | 185 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Ophthalmology | |
| pubs.organisational-group | Ophthalmology, Vitreoretinal Diseases & Surgery | |
| pubs.organisational-group | Medicine, Geriatrics | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Psychology and Neuroscience | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Geriatric Behavioral Health | |
| pubs.organisational-group | Center for Cognitive Neuroscience | |
| pubs.organisational-group | Trinity College of Arts & Sciences | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Immunology | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Duke-UNC Center for Brain Imaging and Analysis | |
| pubs.publication-status | Published | |
| pubs.volume | 95 |
Files
Original bundle
- Name:
- Zuo 2020 MD and memory.pdf
- Size:
- 1.13 MB
- Format:
- Adobe Portable Document Format
- Description:
- Published version