Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.

dc.contributor.author

Sun, Yan

dc.contributor.author

Yu, Wenbin

dc.contributor.author

Sturgis, Erich M

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Peng, Wei

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Lei, Dapeng

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Wei, Qingyi

dc.contributor.author

Song, Xicheng

dc.contributor.author

Li, Guojun

dc.date.accessioned

2019-02-01T15:28:26Z

dc.date.available

2019-02-01T15:28:26Z

dc.date.issued

2016-02-08

dc.date.updated

2019-02-01T15:28:23Z

dc.description.abstract

FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whether tumor sites contribute to the association between FAS/FASL polymorphisms and risk for second primary malignancy (SPM).In this study, FAS670 A > G, FAS1377 G > A, FASL124 A > G, and FASL844C > T polymorphisms were genotyped in 752 OPC and 777 non-OPC patients. Both univariate and multivariable cox proportional hazard models were used to assess the associations.The univariate and multivariable analyses showed that patients with index OPC and FASL844 CT/TT genotype had significantly increased risk of SPM (cHR, 2.5; 95% CI, 1.1-5.8, P = 0.043 and aHR, 2.7; 95% CI, 1.2-6.0, P = 0.032) compared with those with FASL844 CC genotype as the reference group, while index non-OPC patients with FAS670 AG/GG and FasL844 CT/TT genotypes had significantly increased risk of SPM (cHR, 2.2 and 1.8; 95% CI, 1.2-5.7 and 1.1-3.2; and P = 0.04 and 0.041, respectively and aHR, 2.4 and 1.7; 95% CI, 1.1-5.1 and 1.0-3.0; and P = 0.043 and 0.049, respectively) compared with their corresponding AA and CC genotypes . Moreover, patients carrying more FAS/FASL variants significantly increased risk of SPM among index non-OPC patients. The stratified analysis showed that smoking status differently modified the associations between FAS/FASL polymorphisms and risk of SPM among index non-OPC from OPC patients.These results suggested that FAS/FASL polymorphisms might significantly modify SPM risk among patients with SCCHN in a tumor site-specific manner.

dc.identifier

10.1186/s12885-016-2110-y

dc.identifier.issn

1471-2407

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1471-2407

dc.identifier.uri

https://hdl.handle.net/10161/18026

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

BMC cancer

dc.relation.isversionof

10.1186/s12885-016-2110-y

dc.subject

Humans

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Carcinoma, Squamous Cell

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Head and Neck Neoplasms

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Neoplasms, Second Primary

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Antigens, CD95

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Proportional Hazards Models

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Risk Factors

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Apoptosis

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Polymorphism, Genetic

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Aged

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Middle Aged

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Female

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Male

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Fas Ligand Protein

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Promoter Regions, Genetic

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Genetic Association Studies

dc.title

Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.

dc.type

Journal article

duke.contributor.orcid

Wei, Qingyi|0000-0002-3845-9445

pubs.begin-page

70

pubs.issue

1

pubs.organisational-group

School of Medicine

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Duke

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Duke Cancer Institute

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Institutes and Centers

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Population Health Sciences

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Medicine, Medical Oncology

pubs.organisational-group

Medicine

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

16

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