The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

Adeloye, Davies

Elneima, Omer

Daines, Luke

Poinasamy, Krisnah

Quint, Jennifer K

Walker, Samantha

Brightling, Chris E

Siddiqui, Salman

Hurst, John R

Chalmers, James D

Pfeffer, Paul E

Novotny, Petr

Drake, Thomas M

Heaney, Liam G

Rudan, Igor

Sheikh, Aziz

De Soyza, Anthony

International COVID-19 Airways Diseases Group

2022-07-01T14:06:56Z

2022-07-01T14:06:56Z

2021-12

2022-07-01T14:06:55Z

Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.

S2213-2600(21)00286-1

2213-2600

2213-2619

https://hdl.handle.net/10161/25423

eng

Elsevier BV

The Lancet. Respiratory medicine

10.1016/s2213-2600(21)00286-1

International COVID-19 Airways Diseases Group

Humans

Respiration Disorders

Consensus

Research

COVID-19

SARS-CoV-2

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

Journal article

1467

1478

12

Duke

School of Medicine

Clinical Science Departments

Medicine

Pathology

Surgery

Medicine, Pulmonary, Allergy, and Critical Care Medicine

Surgery, Surgical Sciences

Published

9