Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.

Hsu, S Tammy

Ngo, Hoan T

Stinnett, Sandra S

Cheung, Nathan L

House, Robert J

Kelly, Michael P

Chen, Xi

Enyedi, Laura B

Prakalapakorn, S Grace

Materin, Miguel A

El-Dairi, Mays A

Jaffe, Glenn J

Freedman, Sharon F

Toth, Cynthia A

Vajzovic, Lejla

2020-07-15T14:47:20Z

2020-07-15T14:47:20Z

2019-12

2020-07-15T14:47:19Z

PURPOSE:To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN:Prospective cross-sectional study. PARTICIPANTS:One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years; range, 9 weeks-17 years) treated at the Duke University Eye Center. METHODS:We imaged 135 maculae of 89 pediatric patients using the standard Spectralis tabletop and investigational Spectralis with Flex module devices, both equipped with investigational OCTA software (Heidelberg Engineering, Heidelberg, Germany). OCT angiography images of the superficial vascular complex (SVC) and deep vascular complex (DVC) were analyzed for foveal avascular zone (FAZ) area and superficial and deep vessel density. We assessed effects of age, gender, race, axial length (AL), and central subfield thickness on FAZ and vessel density. Patients with both eyes imaged were assessed for agreement between the FAZ and vessel densities of the left and right eyes. MAIN OUTCOME MEASURES:The FAZ area, as well as vessel area density (VAD) and vessel length density (VLD) in the SVC and DVC. RESULTS:The FAZ varied significantly with race; white patients showed a significantly smaller FAZ than black patients (mean difference, 0.11 mm2; P = 0.004). The FAZ did not vary with age, gender, or AL (P > 0.05). In the SVC, VAD and VLD varied significantly with age (P < 0.001) and AL (R2 = 0.46; P < 0.001) but not gender (P > 0.05). The SVC VLD was significantly different between races and ethnicities (P = 0.037), but VAD was not (P < 0.05). In the DVC, VAD and VLD also varied significantly with age (P < 0.001) and AL (R2 = 0.46; P < 0.001) but not gender or race (P > 0.05). There was excellent agreement between the right and left eyes for FAZ (intraclass correlation [ICC], 0.97), SVC VLD (ICC, 1.00), and DVC VLD (ICC, 1.00). CONCLUSIONS:Quantitative studies of pediatric perifoveal vasculature should consider age, race, and AL. In eyes with unilateral disease, the perifoveal vasculature in the unaffected eye may be used as a control comparison because there is excellent agreement between eyes.

S0161-6420(19)30734-1

0161-6420

1549-4713

https://hdl.handle.net/10161/21187

eng

Elsevier BV

Ophthalmology

10.1016/j.ophtha.2019.06.028

Retinal Vessels

Macula Lutea

Humans

Tomography, Optical Coherence

Fluorescein Angiography

Prospective Studies

Cross-Sectional Studies

Age Factors

Visual Acuity

Adolescent

Child

Child, Preschool

Infant

Ethnic Groups

Female

Male

Microvessels

Axial Length, Eye

Healthy Volunteers

Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.

Journal article

Stinnett, Sandra S|0000-0001-7192-0195

Cheung, Nathan L|0000-0001-9006-1605

El-Dairi, Mays A|0000-0002-4365-9038

Toth, Cynthia A|0000-0002-2324-0854

1703

1711

12

School of Medicine

Ophthalmology, Neuro-Ophthalmology

Duke

Ophthalmology

Clinical Science Departments

Pediatrics

Ophthalmology, Vitreoretinal Diseases & Surgery

Duke Global Health Institute

University Institutes and Centers

Institutes and Provost's Academic Units

Biostatistics & Bioinformatics

Basic Science Departments

Biomedical Engineering

Pratt School of Engineering

Duke Cancer Institute

Radiation Oncology

Institutes and Centers

Published

126