Association of chronic non-cancer pain status and buprenorphine treatment retention among individuals with opioid use disorder: Results from electronic health record data.
| dc.contributor.author | John, William S | |
| dc.contributor.author | Mannelli, Paolo | |
| dc.contributor.author | Hoyle, Rick H | |
| dc.contributor.author | Greenblatt, Lawrence | |
| dc.contributor.author | Wu, Li-Tzy | |
| dc.date.accessioned | 2023-03-07T14:55:09Z | |
| dc.date.available | 2023-03-07T14:55:09Z | |
| dc.date.issued | 2022-06 | |
| dc.date.updated | 2023-03-07T14:55:08Z | |
| dc.description.abstract | BackgroundAlthough chronic non-cancer pain (CNCP) is common among individuals with opioid use disorder (OUD), its impact on buprenorphine treatment retention is unclear. The goal of this study was to use electronic health record (EHR) data to examine the association of CNCP status and 6-month buprenorphine retention among patients with OUD.MethodsWe analyzed EHR data of patients with OUD who received buprenorphine treatment in an academic healthcare system between 2010 and 2020 (N = 676). We used Kaplan-Meier curves and Cox proportional hazards regression to estimate risk of buprenorphine treatment discontinuation (≥90 days between subsequent prescriptions). We used Poisson regression to estimate the association of CNCP and the number of buprenorphine prescriptions over 6 months.ResultsCompared to those without CNCP, a higher proportion of patients with CNCP were of older age and had comorbid diagnoses for psychiatric and substance use disorders. There were no differences in the probability of buprenorphine treatment continuation over 6 months by CNCP status (p = 0.15). In the adjusted cox regression model, the presence of CNCP was not associated with time to buprenorphine treatment discontinuation (HR = 0.90, p = 0.28). CNCP status was associated with a higher number of prescriptions over 6 months (IRR = 1.20, p < 0.01).ConclusionsThese findings suggest that the presence of CNCP alone cannot be reliably associated with buprenorphine retention in patients with OUD. Nonetheless, providers should be aware of the association between CNCP and greater psychiatric comorbidity among patients with OUD when developing treatment plans. Research on the influence of additional characteristics of CNCP on treatment retention is needed. | |
| dc.identifier | S2772-7246(22)00026-9 | |
| dc.identifier.issn | 2772-7246 | |
| dc.identifier.issn | 2772-7246 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Drug and alcohol dependence reports | |
| dc.relation.isversionof | 10.1016/j.dadr.2022.100048 | |
| dc.subject | Buprenorphine | |
| dc.subject | Chronic pain | |
| dc.subject | Opioid use disorder | |
| dc.title | Association of chronic non-cancer pain status and buprenorphine treatment retention among individuals with opioid use disorder: Results from electronic health record data. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Mannelli, Paolo|0000-0002-7834-6138 | |
| duke.contributor.orcid | Hoyle, Rick H|0000-0003-0900-2814 | |
| duke.contributor.orcid | Wu, Li-Tzy|0000-0002-5909-2259 | |
| pubs.begin-page | 100048 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Sanford School of Public Policy | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Trinity College of Arts & Sciences | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Medicine, General Internal Medicine | |
| pubs.organisational-group | Psychology & Neuroscience | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Psychiatry, Child & Family Mental Health & Community Psychiatry | |
| pubs.organisational-group | Center for Child and Family Policy | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology | |
| pubs.publication-status | Published | |
| pubs.volume | 3 |
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