Faces evoke spatially differentiated patterns of BOLD activation and deactivation.

Pelphrey, Kevin A

Mack, Peter B

Song, Allen

Güzeldere, Güven

McCarthy, Gregory

England

2013-04-29T19:27:53Z

2003-05-23

Using fMRI techniques sensitive to blood oxygen-level dependent (BOLD) contrast, we measured brain activity in participants (n=8) as they viewed images of faces presented periodically within a continuously changing montage of common objects. Consistent with prior studies, we identified regions of ventral extrastriate cortex, primarily in the fusiform and inferior temporal gyri and nearby cortex, that were activated by faces as measured by an increase in BOLD signal. In addition, we made the novel observation that faces deactivated other areas of ventral extrastriate cortex, primarily in the lingual and parahippocampal gyri and medial to activations. These deactivated regions, identified by a decrease in BOLD signal, may reflect populations of neurons that decrease their activity when faces appear, possibly as a consequence of category-specific inhibition.

http://www.ncbi.nlm.nih.gov/pubmed/12802182

0959-4965

https://hdl.handle.net/10161/6962

eng

Ovid Technologies (Wolters Kluwer Health)

Neuroreport

10.1097/01.wnr.0000074345.81633.ad

Adult

Brain

Brain Mapping

Face

Female

Humans

Magnetic Resonance Imaging

Male

Photic Stimulation

Faces evoke spatially differentiated patterns of BOLD activation and deactivation.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/12802182

955

959

7

Basic Science Departments

Biomedical Engineering

Clinical Science Departments

Duke

Duke Cancer Institute

Duke Institute for Brain Sciences

Institutes and Centers

Institutes and Provost's Academic Units

Neurobiology

Pratt School of Engineering

Psychiatry & Behavioral Sciences

Radiology

School of Medicine

University Institutes and Centers

Published

14