Impact of surgical approach on short- and long-term outcomes in gastroenteropancreatic neuroendocrine carcinomas.
| dc.contributor.author | Chen, Qichen | |
| dc.contributor.author | Rhodin, Kristen E | |
| dc.contributor.author | Li, Kan | |
| dc.contributor.author | Kanu, Elishama | |
| dc.contributor.author | Zani, Sabino | |
| dc.contributor.author | Lidsky, Michael E | |
| dc.contributor.author | Zhao, Jianjun | |
| dc.contributor.author | Wei, Qingyi | |
| dc.contributor.author | Luo, Sheng | |
| dc.contributor.author | Zhao, Hong | |
| dc.date.accessioned | 2023-08-01T13:23:57Z | |
| dc.date.available | 2023-08-01T13:23:57Z | |
| dc.date.issued | 2023-06 | |
| dc.date.updated | 2023-08-01T13:23:56Z | |
| dc.description.abstract | BackgroundLiterature is lacking on the impact of advancements in minimally invasive surgery (MIS) on outcomes for patients with gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs). Herein, we compared perioperative and oncologic outcomes among patients with GEP-NECs undergoing open, laparoscopic, and robotic resection.MethodsPatients with GEP-NECs diagnosed 2010-2019 were identified from the National Cancer Database (NCDB). We used the inverse probability of treatment weighting method to account for selection bias. Patients were stratified by surgical approach; and pairwise comparisons were conducted by analyzing short- and long-term outcomes.ResultsReceipt of MIS increased from 34.2% in 2010 to 67.5 % in 2019. Altogether, 6560 patients met study criteria: 3444 (52.5%) underwent open resection, 2783 (42.4%) underwent laparoscopic resection and 333 (5.1%) underwent robotic resection. Compared with open resection, laparoscopic or robotic resection were associated with shorter post-operative length of stay, reduced 30-day and 90-day post-operative mortality, and prolonged overall survival (OS). Compared with laparoscopic resection, robotic resection was associated with reduced 90-day post-operative mortality, however, there was no significant difference in OS.ConclusionThis NCDB analysis demonstrates that MIS approaches for treating GEP-NECs have become more common, with improved perioperative mortality, shorter post-operative length of stay and favorable OS, compared with open resection. | |
| dc.identifier | S1365-182X(23)00557-9 | |
| dc.identifier.issn | 1365-182X | |
| dc.identifier.issn | 1477-2574 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | HPB : the official journal of the International Hepato Pancreato Biliary Association | |
| dc.relation.isversionof | 10.1016/j.hpb.2023.06.008 | |
| dc.title | Impact of surgical approach on short- and long-term outcomes in gastroenteropancreatic neuroendocrine carcinomas. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Zani, Sabino|0000-0003-1939-4778 | |
| duke.contributor.orcid | Wei, Qingyi|0000-0002-3845-9445|0000-0003-4115-4439 | |
| duke.contributor.orcid | Luo, Sheng|0000-0003-4214-5809 | |
| pubs.begin-page | S1365-182X(23)00557-9 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Pratt School of Engineering | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Staff | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Biostatistics & Bioinformatics | |
| pubs.organisational-group | Thomas Lord Department of Mechanical Engineering and Materials Science | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Medicine, Medical Oncology | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Duke Global Health Institute | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Surgical Oncology | |
| pubs.organisational-group | Biostatistics & Bioinformatics, Division of Biostatistics | |
| pubs.publication-status | Published |