A mathematical model for persistent post-CSD vasoconstriction.

dc.contributor.author

Xu, Shixin

dc.contributor.author

Chang, Joshua C

dc.contributor.author

Chang, Joshua C

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Chow, Carson C

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Brennan, KC

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Huang, Huaxiong

dc.date.accessioned

2021-07-20T14:39:37Z

dc.date.available

2021-07-20T14:39:37Z

dc.date.issued

2020-07-15

dc.date.updated

2021-07-20T14:39:35Z

dc.description.abstract

Cortical spreading depression (CSD) is the propagation of a relatively slow wave in cortical brain tissue that is linked to a number of pathological conditions such as stroke and migraine. Most of the existing literature investigates the dynamics of short term phenomena such as the depolarization and repolarization of membrane potentials or large ion shifts. Here, we focus on the clinically-relevant hour-long state of neurovascular malfunction in the wake of CSDs. This dysfunctional state involves widespread vasoconstriction and a general disruption of neurovascular coupling. We demonstrate, using a mathematical model, that dissolution of calcium that has aggregated within the mitochondria of vascular smooth muscle cells can drive an hour-long disruption. We model the rate of calcium clearance as well as the dynamical implications on overall blood flow. Based on reaction stoichiometry, we quantify a possible impact of calcium phosphate dissolution on the maintenance of F0F1-ATP synthase activity.

dc.identifier

PCOMPBIOL-D-19-01345

dc.identifier.issn

1553-734X

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1553-7358

dc.identifier.uri

https://hdl.handle.net/10161/23460

dc.language

eng

dc.publisher

Public Library of Science (PLoS)

dc.relation.ispartof

PLoS computational biology

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10.1371/journal.pcbi.1007996

dc.subject

Cerebral Cortex

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Endoplasmic Reticulum

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Mitochondria

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Cytosol

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Humans

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Calcium Phosphates

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Oxygen

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Calcium

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Proton-Translocating ATPases

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Adenosine Triphosphate

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Oscillometry

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Membrane Potentials

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Phosphorylation

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Cerebrovascular Circulation

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Vasoconstriction

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Models, Theoretical

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Stroke

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Cortical Spreading Depression

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Gray Matter

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Neurovascular Coupling

dc.title

A mathematical model for persistent post-CSD vasoconstriction.

dc.type

Journal article

duke.contributor.orcid

Xu, Shixin|0000-0002-8207-7313

pubs.begin-page

e1007996

pubs.issue

7

pubs.organisational-group

Duke Kunshan University

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Duke Kunshan University Faculty

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Duke

pubs.publication-status

Published

pubs.volume

16

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