Depression, quality of life, and medical resource utilization in sickle cell disease.

Adam, Soheir S

Flahiff, Charlene M

Kamble, Shital

Telen, Marilyn J

Reed, Shelby D

De Castro, Laura M

2020-02-27T15:57:00Z

2020-02-27T15:57:00Z

2017-10-12

2020-02-27T15:56:59Z

Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center. HRQoL was assessed using the SF36 form, and data were collected on medical resource utilization and corresponding cost. Neurocognitive functions were assessed using the CNS Vital Signs tool. Pain diaries were used to record daily pain. Out of 142 enrolled patients, 42 (35.2%) had depression. Depression was associated with worse physical and mental HRQoL scores (P < .0001 and P < .0001, respectively). Mean total inpatient costs ($25 000 vs $7487, P = .02) and total health care costs ($30 665 vs $13 016, P = .01) were significantly higher in patients with depression during the 12 months preceding diagnosis. Similarly, during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients ($13 766 vs $8670, P = .04). Depression is prevalent in adult patients with SCD and is associated with worse HRQoL and higher total health care costs. Efforts should focus on prevention, early diagnosis, and therapy for depression in SCD.

2017/006940

2473-9529

2473-9537

https://hdl.handle.net/10161/20236

eng

American Society of Hematology

Blood advances

10.1182/bloodadvances.2017006940

Science & Technology

Life Sciences & Biomedicine

Hematology

CLINICAL-TRIAL CONSORTIUM

MAJOR DEPRESSION

CHRONIC PAIN

COPING STRATEGIES

HEALTH-CARE

CHILDREN

ADULTS

POPULATION

INVENTORY

ADJUSTMENT

Depression, quality of life, and medical resource utilization in sickle cell disease.

Journal article

Telen, Marilyn J|0000-0003-3809-1780

Reed, Shelby D|0000-0002-7654-4464

1983

1992

23

School of Medicine

Duke Cancer Institute

Duke Clinical Research Institute

Population Health Sciences

Duke Science & Society

Medicine, General Internal Medicine

Duke

Institutes and Centers

Basic Science Departments

Initiatives

Institutes and Provost's Academic Units

Medicine

Clinical Science Departments

Medicine, Hematology

Duke Global Health Institute

Pathology

University Institutes and Centers

Staff

Published

1