Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees.

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Liu, Pinghuang

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Yates, Nicole L

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Shen, Xiaoying

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Bonsignori, Mattia

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Moody, M Anthony

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Liao, Hua-Xin

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Fong, Youyi

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Alam, S Munir

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Overman, R Glenn

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Denny, Thomas

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Ferrari, Guido

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Ochsenbauer, Christina

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Kappes, John C

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Polonis, Victoria R

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Pitisuttithum, Punnee

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Kaewkungwal, Jaranit

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Nitayaphan, Sorachai

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Rerks-Ngarm, Supachai

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Montefiori, David C

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Gilbert, Peter

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Michael, Nelson L

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Kim, Jerome H

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Haynes, Barton F

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Tomaras, Georgia D

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United States

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2017-06-01T20:27:28Z

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2017-06-01T20:27:28Z

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2013-07

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The detailed examination of the antibody repertoire from RV144 provides a unique template for understanding potentially protective antibody functions. Some potential immune correlates of protection were untested in the correlates analyses due to inherent assay limitations, as well as the need to keep the correlates analysis focused on a limited number of endpoints to achieve statistical power. In an RV144 pilot study, we determined that RV144 vaccination elicited antibodies that could bind infectious virions (including the vaccine strains HIV-1 CM244 and HIV-1 MN and an HIV-1 strain expressing transmitted/founder Env, B.WITO.c). Among vaccinees with the highest IgG binding antibody profile, the majority (78%) captured the infectious vaccine strain virus (CM244), while a smaller proportion of vaccinees (26%) captured HIV-1 transmitted/founder Env virus. We demonstrated that vaccine-elicited HIV-1 gp120 antibodies of multiple specificities (V3, V2, conformational C1, and gp120 conformational) mediated capture of infectious virions. Although capture of infectious HIV-1 correlated with other humoral immune responses, the extent of variation between these humoral responses and virion capture indicates that virion capture antibodies occupy unique immunological space.

dc.identifier

https://www.ncbi.nlm.nih.gov/pubmed/23658446

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JVI.02737-12

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1098-5514

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https://hdl.handle.net/10161/14726

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eng

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American Society for Microbiology

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J Virol

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10.1128/JVI.02737-12

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AIDS Vaccines

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Antibodies, Neutralizing

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Antibodies, Viral

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Antibody Specificity

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HIV Envelope Protein gp120

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HIV-1

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Humans

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Immunoglobulin G

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Pilot Projects

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Viral Vaccines

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Virion

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Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees.

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Journal article

duke.contributor.orcid

Shen, Xiaoying|0000-0001-8076-1931|0000-0002-8387-3952

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Bonsignori, Mattia|0000-0003-2973-2101

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Moody, M Anthony|0000-0002-3890-5855

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Ferrari, Guido|0000-0001-7747-3349

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Montefiori, David C|0000-0003-0856-6319

duke.contributor.orcid

Tomaras, Georgia D|0000-0001-8076-1931

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/23658446

pubs.begin-page

7828

pubs.end-page

7836

pubs.issue

14

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Basic Science Departments

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Clinical Science Departments

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Duke

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Duke Cancer Institute

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Duke Human Vaccine Institute

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Immunology

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Institutes and Centers

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Medicine

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Medicine, Duke Human Vaccine Institute

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Molecular Genetics and Microbiology

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Pathology

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Pediatrics

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Pediatrics, Infectious Diseases

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School of Medicine

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Surgery

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Surgery, Surgical Sciences

pubs.publication-status

Published

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87

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