The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk.

Mahlokozera, T

Kang, HH

Goonetilleke, N

Stacey, AR

Lovingood, RV

Denny, TN

Kalilani, L

Bunn, JE

Meshnick, SR

Borrow, P

Letvin, NL

Permar, SR

Immunology, Center for HIVAIDS Vaccine

Gray, Clive M

United States

2017-06-02T12:34:40Z

2017-06-02T12:34:40Z

2011

BACKGROUND: The risk of postnatal HIV transmission is associated with the magnitude of the milk virus load. While HIV-specific cellular immune responses control systemic virus load and are detectable in milk, the contribution of these responses to the control of virus load in milk is unknown. METHODS: We assessed the magnitude of the immunodominant GagRY11 and subdominant EnvKY9-specific CD8+ T lymphocyte response in blood and milk of 10 A*3002+, HIV-infected Malawian women throughout the period of lactation and correlated this response to milk virus RNA load and markers of breast inflammation. RESULTS: The magnitude and kinetics of the HIV-specific CD8+ T lymphocyte responses were discordant in blood and milk of the right and left breast, indicating independent regulation of these responses in each breast. However, there was no correlation between the magnitude of the HIV-specific CD8+ T lymphocyte response and the milk virus RNA load. Further, there was no correlation between the magnitude of this response and markers of breast inflammation. CONCLUSIONS: The magnitude of the HIV-specific CD8+ T lymphocyte response in milk does not appear to be solely determined by the milk virus RNA load and is likely only one of the factors contributing to maintenance of low virus load in milk.

https://www.ncbi.nlm.nih.gov/pubmed/21886819

PONE-D-11-09695

1932-6203

https://hdl.handle.net/10161/14732

eng

Public Library of Science (PLoS)

PLoS One

10.1371/journal.pone.0023735

Breast

CD8-Positive T-Lymphocytes

Female

HIV

Humans

Kinetics

Lactation

Malawi

Milk, Human

Mucous Membrane

RNA, Viral

T-Cell Antigen Receptor Specificity

Viral Load

The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk.

Journal article

https://www.ncbi.nlm.nih.gov/pubmed/21886819

e23735

8

Basic Science Departments

Clinical Science Departments

Duke

Duke Human Vaccine Institute

Immunology

Institutes and Centers

Medicine

Medicine, Duke Human Vaccine Institute

Molecular Genetics and Microbiology

Pediatrics

Pediatrics, Infectious Diseases

School of Medicine

Published

6