Targeted repair of heart injury by stem cells fused with platelet nanovesicles.

dc.contributor.author

Tang, Junnan

dc.contributor.author

Su, Teng

dc.contributor.author

Huang, Ke

dc.contributor.author

Dinh, Phuong-Uyen

dc.contributor.author

Wang, Zegen

dc.contributor.author

Vandergriff, Adam

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Hensley, Michael T

dc.contributor.author

Cores, Jhon

dc.contributor.author

Allen, Tyler

dc.contributor.author

Li, Taosheng

dc.contributor.author

Sproul, Erin

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Mihalko, Emily

dc.contributor.author

Lobo, Leonard J

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Ruterbories, Laura

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Lynch, Alex

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Brown, Ashley

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Caranasos, Thomas G

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Shen, Deliang

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Stouffer, George A

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Gu, Zhen

dc.contributor.author

Zhang, Jinying

dc.contributor.author

Cheng, Ke

dc.date.accessioned

2022-12-04T18:15:10Z

dc.date.available

2022-12-04T18:15:10Z

dc.date.issued

2018-01

dc.date.updated

2022-12-04T18:15:07Z

dc.description.abstract

Stem cell transplantation, as used clinically, suffers from low retention and engraftment of the transplanted cells. Inspired by the ability of platelets to recruit stem cells to sites of injury on blood vessels, we hypothesized that platelets might enhance the vascular delivery of cardiac stem cells (CSCs) to sites of myocardial infarction injury. Here, we show that CSCs with platelet nanovesicles fused onto their surface membranes express platelet surface markers that are associated with platelet adhesion to injury sites. We also find that the modified CSCs selectively bind collagen-coated surfaces and endothelium-denuded rat aortas, and that in rat and porcine models of acute myocardial infarction the modified CSCs increase retention in the heart and reduce infarct size. Platelet-nanovesicle-fused CSCs thus possess the natural targeting and repairing ability of their parental cell types. This stem cell manipulation approach is fast, straightforward and safe, does not require genetic alteration of the cells, and should be generalizable to multiple cell types.

dc.identifier

10.1038/s41551-017-0182-x

dc.identifier.issn

2157-846X

dc.identifier.issn

2157-846X

dc.identifier.uri

https://hdl.handle.net/10161/26328

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Nature biomedical engineering

dc.relation.isversionof

10.1038/s41551-017-0182-x

dc.title

Targeted repair of heart injury by stem cells fused with platelet nanovesicles.

dc.type

Journal article

duke.contributor.orcid

Su, Teng|0000-0001-7888-0763

duke.contributor.orcid

Allen, Tyler|0000-0002-8729-6339

pubs.begin-page

17

pubs.end-page

26

pubs.issue

1

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Medicine

pubs.organisational-group

Medicine, Cardiology

pubs.publication-status

Published

pubs.volume

2

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