Accelerating stem cell trials for Alzheimer's disease.

dc.contributor.author

Hunsberger, Joshua G

dc.contributor.author

Rao, Mahendra

dc.contributor.author

Kurtzberg, Joanne

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Bulte, Jeff WM

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Atala, Anthony

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LaFerla, Frank M

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Greely, Henry T

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Sawa, Akira

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Gandy, Sam

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Schneider, Lon S

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Doraiswamy, P Murali

dc.date.accessioned

2022-03-23T19:07:28Z

dc.date.available

2022-03-23T19:07:28Z

dc.date.issued

2016-02

dc.date.updated

2022-03-23T19:07:28Z

dc.description.abstract

At present, no effective cure or prophylaxis exists for Alzheimer's disease. Symptomatic treatments are modestly effective and offer only temporary benefit. Advances in induced pluripotent stem cell (iPSC) technology have the potential to enable development of so-called disease-in-a-dish personalised models to study disease mechanisms and reveal new therapeutic approaches, and large panels of iPSCs enable rapid screening of potential drug candidates. Different cell types can also be produced for therapeutic use. In 2015, the US Food and Drug Administration granted investigational new drug approval for the first phase 2A clinical trial of ischaemia-tolerant mesenchymal stem cells to treat Alzheimer's disease in the USA. Similar trials are either underway or being planned in Europe and Asia. Although safety and ethical concerns remain, we call for the acceleration of human stem cell-based translational research into the causes and potential treatments of Alzheimer's disease.

dc.identifier

S1474-4422(15)00332-4

dc.identifier.issn

1474-4422

dc.identifier.issn

1474-4465

dc.identifier.uri

https://hdl.handle.net/10161/24635

dc.language

eng

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Elsevier BV

dc.relation.ispartof

The Lancet. Neurology

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10.1016/s1474-4422(15)00332-4

dc.subject

Humans

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Alzheimer Disease

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Mesenchymal Stem Cell Transplantation

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Clinical Trials as Topic

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Induced Pluripotent Stem Cells

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Accelerating stem cell trials for Alzheimer's disease.

dc.type

Journal article

duke.contributor.orcid

Kurtzberg, Joanne|0000-0002-3370-0703

pubs.begin-page

219

pubs.end-page

230

pubs.issue

2

pubs.organisational-group

Duke

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School of Medicine

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Clinical Science Departments

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Institutes and Centers

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Medicine

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Pathology

pubs.organisational-group

Pediatrics

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Medicine, Geriatrics

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Duke Cancer Institute

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Institutes and Provost's Academic Units

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University Institutes and Centers

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Duke Institute for Brain Sciences

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Center for the Study of Aging and Human Development

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Initiatives

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Duke Science & Society

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Duke Innovation & Entrepreneurship

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Pediatrics, Transplant and Cellular Therapy

pubs.publication-status

Published

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15

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