Central venous catheters are associated with thrombosis among adult inpatients undergoing therapeutic plasma exchange.
| dc.contributor.author | Soares Ferreira Júnior, Alexandre | |
| dc.contributor.author | Boyle, Stephen H | |
| dc.contributor.author | Kuchibhatla, Maragatha | |
| dc.contributor.author | Onwuemene, Oluwatoyosi A | |
| dc.date.accessioned | 2023-04-07T12:48:54Z | |
| dc.date.available | 2023-04-07T12:48:54Z | |
| dc.date.issued | 2022-08 | |
| dc.date.updated | 2023-04-07T12:48:53Z | |
| dc.description.abstract | BackgroundFor inpatients undergoing therapeutic plasma exchange (TPE) in the United States, the primary mode of venous access is the central venous catheter (CVC). To evaluate the impact of CVC on thrombosis outcomes of patients undergoing TPE, we analyzed the National Inpatient Sample (NIS) database.Study design and methodsIn a cross-sectional analysis of the NIS, we identified hospital discharges of adult patients treated with TPE. Cases were classified into two groups based on CVC status. The primary outcome was thrombosis. Secondary outcomes were major bleeding, packed red blood cell (PRBC) transfusion, in-hospital mortality, hospital length of stay (LOS), and charges.ResultsAmong 9863 TPE-treated discharges, CVC was used in 5988 (60%). These numbers correspond to weighted national estimates of 49 315 and 29 940, respectively. There was a positive and significant association between CVC and thrombosis (OR = 1.23, 95% 1.04-1.46, P = 0.0174), PRBC transfusion (OR = 1.15, 95% 1.03-1.29, P = 0.0121), in-hospital mortality (OR = 1.36, 95% 1.10-1.68, P = 0.0043), hospital LOS (15.63 vs 12.45 days, P < 0.0001) and hospital charges ($166 387 vs. $132 655, P < 0.0001).ConclusionIn hospitalized patients undergoing TPE, CVC use is associated with increased rates of thrombosis. Future studies are needed to investigate strategies to decrease CVC use and/or prevent CVC-associated complications in TPE-treated inpatients. | |
| dc.identifier.issn | 0733-2459 | |
| dc.identifier.issn | 1098-1101 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | Journal of clinical apheresis | |
| dc.relation.isversionof | 10.1002/jca.21975 | |
| dc.subject | Humans | |
| dc.subject | Thrombosis | |
| dc.subject | Plasma Exchange | |
| dc.subject | Catheterization, Central Venous | |
| dc.subject | Cross-Sectional Studies | |
| dc.subject | Adult | |
| dc.subject | Inpatients | |
| dc.subject | United States | |
| dc.subject | Central Venous Catheters | |
| dc.title | Central venous catheters are associated with thrombosis among adult inpatients undergoing therapeutic plasma exchange. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Onwuemene, Oluwatoyosi A|0000-0001-7266-7101 | |
| pubs.begin-page | 340 | |
| pubs.end-page | 347 | |
| pubs.issue | 4 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Staff | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Biostatistics & Bioinformatics | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Medicine, Hematology | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences | |
| pubs.publication-status | Published | |
| pubs.volume | 37 |
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