Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.

Tyson, Crystal C

Kuchibhatla, Maragatha

Patel, Uptal D

Pun, Patrick H

Chang, Alex

Nwankwo, Chinazo

Joseph, Michael A

Svetkey, Laura P

United States

2015-10-09T17:14:05Z

OBJECTIVES: Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure in adults with hypertension, how kidney function impacts this effect is not known. We evaluated whether Estimated Glomerular Filtration Rate (eGFR) modifies the effect of the DASH diet on blood pressure, markers of mineral metabolism, and markers of kidney function. METHODS: Secondary analysis of the DASH-Sodium trial, a multicenter, randomized, controlled human feeding study that evaluated the blood pressure lowering effect of the DASH diet at three levels of sodium intake. Data from 92 participants with pre-hypertension or stage 1 hypertension during the 3450 mg /day sodium diet assignment contributed to this analysis. Stored frozen plasma and urine specimens were used to measure kidney related laboratory outcomes. RESULTS: Effects of the DASH diet on blood pressure, phosphorus, intact parathyroid hormone, creatinine, and albuminuria were not modified by baseline eGFR (mean 84.5 ± 18.0 ml/min/1.73 m(2), range 44.1 to 138.6 ml/min/1.73 m(2)) or the presence of chronic kidney disease (N=13%). CONCLUSIONS: The impact of the DASH diet on blood pressure, markers of mineral metabolism, and markers of kidney function does not appear to be modified by eGFR in this small subset of DASH-Sodium trial participants with relatively preserved kidney function. Whether greater reduction in eGFR modifies the effects of DASH on kidney related measures is yet to be determined. A larger study in individuals with more advanced kidney disease is needed to establish the efficacy and safety of the DASH diet in this patient population.

http://www.ncbi.nlm.nih.gov/pubmed/26380159

https://hdl.handle.net/10161/10738

eng

OMICS Publishing Group

J Hypertens (Los Angel)

10.4172/2167-1095.1000168

Blood pressure

Diet

Hypertension

Kidney disease

Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.

Journal article

Pun, Patrick H|0000-0002-9896-8292

Svetkey, Laura P|0000-0002-3675-1282

http://www.ncbi.nlm.nih.gov/pubmed/26380159

Basic Science Departments

Biostatistics & Bioinformatics

Center for the Study of Aging and Human Development

Clinical Science Departments

Duke

Duke Clinical Research Institute

Global Health Institute

Institutes and Centers

Institutes and Provost's Academic Units

Medicine

Medicine, Nephrology

Pediatrics

Pediatrics, Nephrology

Psychiatry & Behavioral Sciences

Psychiatry & Behavioral Sciences, Behavioral Medicine

School of Medicine

University Institutes and Centers

Published

3