Human endotoxin administration as an experimental model in drug development.

dc.contributor.author	Suffredini, AF
dc.contributor.author	Noveck, RJ
dc.coverage.spatial	United States
dc.date.accessioned	2015-12-15T16:20:16Z
dc.date.issued	2014-10
dc.description.abstract	Linking human physiology to inflammatory mechanisms discovered in vitro or in animal models is essential to determine their importance. Innate immunity underlies many of these inflammatory responses in health and disease. Bacterial endotoxin is the quintessential trigger of innate immune responses. When administered to humans, endotoxin has been an important means of demonstrating key inflammatory mechanisms in vivo. Furthermore, endotoxin challenges have provided opportunities to test the effects of novel inflammation-modifying agents in humans.
dc.identifier	http://www.ncbi.nlm.nih.gov/pubmed/25236665
dc.identifier	clpt2014146
dc.identifier.eissn	1532-6535
dc.identifier.uri	https://hdl.handle.net/10161/11171
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Clin Pharmacol Ther
dc.relation.isversionof	10.1038/clpt.2014.146
dc.subject	Anti-Inflammatory Agents
dc.subject	Drug Discovery
dc.subject	Endotoxins
dc.subject	Humans
dc.subject	Infection
dc.subject	Inflammation
dc.title	Human endotoxin administration as an experimental model in drug development.
dc.type	Journal article
pubs.author-url	http://www.ncbi.nlm.nih.gov/pubmed/25236665
pubs.begin-page	418
pubs.end-page	422
pubs.issue	4
pubs.organisational-group	Duke
pubs.organisational-group	Staff
pubs.publication-status	Published
pubs.volume	96

Files

Now showing 1 - 1 of 1