Probing Computation in the Primate Visual System at Single-Cone Resolution.

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2019-03-11

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Abstract

Daylight vision begins when light activates cone photoreceptors in the retina, creating spatial patterns of neural activity. These cone signals are then combined and processed in downstream neural circuits, ultimately producing visual perception. Recent technical advances have made it possible to deliver visual stimuli to the retina that probe this processing by the visual system at its elementary resolution of individual cones. Physiological recordings from nonhuman primate retinas reveal the spatial organization of cone signals in retinal ganglion cells, including how signals from cones of different types are combined to support both spatial and color vision. Psychophysical experiments with human subjects characterize the visual sensations evoked by stimulating a single cone, including the perception of color. Future combined physiological and psychophysical experiments focusing on probing the elementary visual inputs are likely to clarify how neural processing generates our perception of the visual world. Expected final online publication date for the Annual Review of Neuroscience Volume 42 is July 8, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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10.1146/annurev-neuro-070918-050233

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Kling, A, GD Field, DH Brainard and EJ Chichilnisky (2019). Probing Computation in the Primate Visual System at Single-Cone Resolution. Annual review of neuroscience, 42(1). 10.1146/annurev-neuro-070918-050233 Retrieved from https://hdl.handle.net/10161/18195.

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Field

Greg D. Field

Adjunct Associate Professor of Neurobiology

My laboratory studies how the retina processes visual scenes and transmits this information to the brain.  We use multi-electrode arrays to record the activity of hundreds of retina neurons simultaneously in conjunction with transgenic mouse lines and chemogenetics to manipulate neural circuit function. We are interested in three major areas. First, we work to understand how neurons in the retina are functionally connected. Second we are studying how light-adaptation and circadian rhythms alter visual processing in the retina. Finally, we are working to understand the mechanisms of retinal degenerative conditions and we are investigating potential treatments in animal models.


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