Multichannel electrophysiological spike sorting via joint dictionary learning and mixture modeling

dc.contributor.author

Carlson, David E

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Vogelstein, Joshua T

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Wu, Qisong

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Lian, Wenzhao

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Zhou, Mingyuan

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Stoetzner, Colin R

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Kipke, Daryl

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Weber, Douglas

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Dunson, David B

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Carin, Lawrence

dc.date.accessioned

2017-10-01T21:16:34Z

dc.date.available

2017-10-01T21:16:34Z

dc.date.issued

2014-01-01

dc.description.abstract

We propose a methodology for joint feature learning and clustering of multichannel extracellular electrophysiological data, across multiple recording periods for action potential detection and classification (sorting). Our methodology improves over the previous state of the art principally in four ways. First, via sharing information across channels, we can better distinguish between single-unit spikes and artifacts. Second, our proposed "focused mixture model" (FMM) deals with units appearing, disappearing, or reappearing over multiple recording days, an important consideration for any chronic experiment. Third, by jointly learning features and clusters, we improve performance over previous attempts that proceeded via a two-stage learning process. Fourth, by directly modeling spike rate, we improve the detection of sparsely firing neurons. Moreover, our Bayesian methodology seamlessly handles missing data. We present the state-of-the-art performance without requiring manually tuning hyperparameters, considering both a public dataset with partial ground truth and a new experimental dataset. © 2013 IEEE.

dc.identifier.eissn

1558-2531

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0018-9294

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https://hdl.handle.net/10161/15596

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IEEE

dc.relation.ispartof

IEEE Transactions on Biomedical Engineering

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10.1109/TBME.2013.2275751

dc.title

Multichannel electrophysiological spike sorting via joint dictionary learning and mixture modeling

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Journal article

duke.contributor.orcid

Carlson, David E|0000-0003-1005-6385

pubs.begin-page

41

pubs.end-page

54

pubs.issue

1

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Basic Science Departments

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Biostatistics & Bioinformatics

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Civil and Environmental Engineering

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Duke

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Duke Clinical Research Institute

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Duke Institute for Brain Sciences

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Electrical and Computer Engineering

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Institutes and Centers

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Institutes and Provost's Academic Units

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Pratt School of Engineering

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School of Medicine

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Statistical Science

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Trinity College of Arts & Sciences

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University Institutes and Centers

pubs.publication-status

Published

pubs.volume

61

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