Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.
| dc.contributor.author | Salehi, Marzieh | |
| dc.contributor.author | Gastaldelli, Amalia | |
| dc.contributor.author | D'Alessio, David A | |
| dc.coverage.spatial | England | |
| dc.date.accessioned | 2017-12-18T19:58:31Z | |
| dc.date.available | 2017-12-18T19:58:31Z | |
| dc.date.issued | 2017-11-20 | |
| dc.description.abstract | AIMS: Patients with Roux-en-Y gastric bypass surgery (GB) have exaggerated postprandial insulin secretion, which has been attributed to increased meal glucose appearance and enhanced incretin effect. Here we sought to determine β-cell glucose sensitivity in the absence of meal stimulation and insulinotropic gut factors. MATERIALS AND METHODS: Twelve non-diabetic subjects with prior GB, and 7 matched non-surgical controls with normal glucose tolerance were studied. Blood glucose and insulin secretion rates were measured during a graded glucose infusion at increasing and then decreasing rates. Insulin sensitivity (SI ) and glucose effectiveness (SG ) were determined by the minimal model. RESULTS: The GB subjects had comparable SI to the controls. The GB subjects had relative hyperglycemia during highest dose of glucose infusion associated with significantly reduced β-cell glucose sensitivity throughout both step-up (GB: 34±6, CN: 82±9 pmol.min-1 .mM-1 .L, p<0.0001) and step-down (GB: 31±6, CN: 74±9 pmol.min-1 .mM-1 .L, p<0.0001) phases of the glucose infusion. The GB subjects also had reduced SG (GB: 0.04±0.00, CN: 0.07±0.01 min-1 , p = 0.004). CONCLUSION: In the absence of enteric stimuli β-cell sensitivity to changes in glycemia is blunted among individuals with GB, indicating a significant shift in a fundamental property of β-cell function several years after surgery. | |
| dc.identifier | ||
| dc.identifier.eissn | 1463-1326 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | Diabetes Obes Metab | |
| dc.relation.isversionof | 10.1111/dom.13165 | |
| dc.subject | gastric bypass surgery | |
| dc.subject | glucose tolerance | |
| dc.subject | β-cell glucose sensitivity | |
| dc.title | Beta-cell sensitivity to glucose is impaired after gastric bypass surgery. | |
| dc.type | Journal article | |
| duke.contributor.orcid | D'Alessio, David A|0000-0003-4155-4870 | |
| pubs.author-url | ||
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Molecular Physiology Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Endocrinology, Metabolism, and Nutrition | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Temp group - logins allowed | |
| pubs.publication-status | Published online |
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