Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.
| dc.contributor.author | He, Jing | |
| dc.contributor.author | Xu, Yu | |
| dc.contributor.author | Qiu, Li-Xin | |
| dc.contributor.author | Li, Jin | |
| dc.contributor.author | Zhou, Xiao-Yan | |
| dc.contributor.author | Sun, Meng-Hong | |
| dc.contributor.author | Wang, Jiu-Cun | |
| dc.contributor.author | Yang, Ya-Jun | |
| dc.contributor.author | Jin, Li | |
| dc.contributor.author | Wei, Qing-Yi | |
| dc.contributor.author | Wang, Yanong | |
| dc.date.accessioned | 2019-02-01T15:12:20Z | |
| dc.date.available | 2019-02-01T15:12:20Z | |
| dc.date.issued | 2012-01 | |
| dc.date.updated | 2019-02-01T15:12:19Z | |
| dc.description.abstract | BACKGROUND: Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk. METHODS: Three ERCC1 functional SNPs (rs2298881C>A, rs3212986C>A and rs11615G>A) and two XPF/ERCC4 functional SNPs (rs2276466C>G and rs6498486A>C) were genotyped for 1125 gastric adenocarcinoma cases and 1196 cancer-free controls by Taqman assays. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate risk associations, and false-positive report probabilities (FPRP) were calculated for assessing significant findings. RESULTS: ERCC1 rs2298881C and rs11615A variant genotypes were associated with increased gastric cancer risk (adjusted OR=1.33, 95% CI=1.05-1.67 for rs2298881 AC/CC and adjusted OR=1.23, 95% CI=1.05-1.46 for rs11615 AG/AA, compared with their common genotype AA and GG, respectively). Patients with 2-3 ERCC1 risk genotypes had significant increased risk (adjusted OR=1.56, 95% CI=1.27-1.93), compared with those with 0-1 ERCC1 risk genotypes, and this risk was more significantly in subgroups of never drinkers, non-gastric cardia adenocarcinoma (NGCA) and clinical stage I+II. All these risks were not observed for XPF SNPs. CONCLUSIONS: These findings suggest that functional ERCC1 SNPs may contribute to risk of gastric cancer. Larger and well-designed studies with different ethnic populations are needed to validate our findings. | |
| dc.identifier | PONE-D-12-21231 | |
| dc.identifier.issn | 1932-6203 | |
| dc.identifier.issn | 1932-6203 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Public Library of Science (PLoS) | |
| dc.relation.ispartof | PloS one | |
| dc.relation.isversionof | 10.1371/journal.pone.0049308 | |
| dc.subject | Humans | |
| dc.subject | Stomach Neoplasms | |
| dc.subject | Endonucleases | |
| dc.subject | DNA-Binding Proteins | |
| dc.subject | Odds Ratio | |
| dc.subject | Risk Factors | |
| dc.subject | DNA Repair | |
| dc.subject | Genotype | |
| dc.subject | Polymorphism, Single Nucleotide | |
| dc.subject | Asian Continental Ancestry Group | |
| dc.subject | China | |
| dc.title | Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Wei, Qing-Yi|0000-0002-3845-9445|0000-0003-4115-4439 | |
| pubs.begin-page | e49308 | |
| pubs.issue | 11 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Medicine, Medical Oncology | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.publication-status | Published | |
| pubs.volume | 7 |
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