Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy.
dc.contributor.author | Hrushesky, WJ | |
dc.contributor.author | Fader, DJ | |
dc.contributor.author | Berestka, JS | |
dc.contributor.author | Sommer, M | |
dc.contributor.author | Hayes, J | |
dc.contributor.author | Cope, FO | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2016-03-25T03:52:23Z | |
dc.date.issued | 1991-08 | |
dc.description.abstract | BACKGROUND: The development of a microcomputer-based device permits quick, simple, and noninvasive quantification of the respiratory sinus arrhythmia (RSA) during quiet breathing. METHODS AND RESULTS: We prospectively and serially measured the radionuclide left ventricular ejection fraction and the RSA amplitude in 34 cancer patients receiving up to nine monthly bolus treatments with doxorubicin hydrochloride (60 mg/m2). Of the eight patients who ultimately developed symptomatic doxorubicin-induced congestive heart failure, seven (87.5%) demonstrated a significant decline in RSA amplitude; five of 26 subjects without clinical symptoms of cardiotoxicity (19.2%) showed a similar RSA amplitude decline. On average, significant RSA amplitude decline occurred 3 months before the last planned doxorubicin dose in patients destined to develop clinical congestive heart failure. CONCLUSION: Overall, RSA amplitude abnormality proved to be a more specific predictor of clinically significant congestive heart failure than did serial resting radionuclide ejection fractions. | |
dc.identifier | ||
dc.identifier.issn | 0009-7322 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Ovid Technologies (Wolters Kluwer Health) | |
dc.relation.ispartof | Circulation | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Cardiomyopathies | |
dc.subject | Doxorubicin | |
dc.subject | Female | |
dc.subject | Forecasting | |
dc.subject | Heart Failure | |
dc.subject | Heart Rate | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Sinoatrial Node | |
dc.subject | Stroke Volume | |
dc.subject | Vagus Nerve | |
dc.title | Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy. | |
dc.type | Journal article | |
duke.contributor.orcid | Sommer, M|0000-0001-5061-763X | |
pubs.author-url | ||
pubs.begin-page | 697 | |
pubs.end-page | 707 | |
pubs.issue | 2 | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Biomedical Engineering | |
pubs.organisational-group | Center for Cognitive Neuroscience | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Institute for Brain Sciences | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Neurobiology | |
pubs.organisational-group | Pratt School of Engineering | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | University Institutes and Centers | |
pubs.publication-status | Published | |
pubs.volume | 84 |
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