Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy.

dc.contributor.author

Hrushesky, WJ

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Fader, DJ

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Berestka, JS

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Sommer, M

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Hayes, J

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Cope, FO

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United States

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2016-03-25T03:52:23Z

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1991-08

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BACKGROUND: The development of a microcomputer-based device permits quick, simple, and noninvasive quantification of the respiratory sinus arrhythmia (RSA) during quiet breathing. METHODS AND RESULTS: We prospectively and serially measured the radionuclide left ventricular ejection fraction and the RSA amplitude in 34 cancer patients receiving up to nine monthly bolus treatments with doxorubicin hydrochloride (60 mg/m2). Of the eight patients who ultimately developed symptomatic doxorubicin-induced congestive heart failure, seven (87.5%) demonstrated a significant decline in RSA amplitude; five of 26 subjects without clinical symptoms of cardiotoxicity (19.2%) showed a similar RSA amplitude decline. On average, significant RSA amplitude decline occurred 3 months before the last planned doxorubicin dose in patients destined to develop clinical congestive heart failure. CONCLUSION: Overall, RSA amplitude abnormality proved to be a more specific predictor of clinically significant congestive heart failure than did serial resting radionuclide ejection fractions.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/1860214

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0009-7322

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https://hdl.handle.net/10161/11768

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eng

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Ovid Technologies (Wolters Kluwer Health)

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Circulation

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Adult

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Aged

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Cardiomyopathies

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Doxorubicin

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Female

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Forecasting

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Heart Failure

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Heart Rate

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Humans

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Male

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Middle Aged

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Sinoatrial Node

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Stroke Volume

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Vagus Nerve

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Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy.

dc.type

Journal article

duke.contributor.orcid

Sommer, M|0000-0001-5061-763X

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/1860214

pubs.begin-page

697

pubs.end-page

707

pubs.issue

2

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Basic Science Departments

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Biomedical Engineering

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Center for Cognitive Neuroscience

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Duke

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Duke Institute for Brain Sciences

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Institutes and Provost's Academic Units

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Neurobiology

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Pratt School of Engineering

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School of Medicine

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University Institutes and Centers

pubs.publication-status

Published

pubs.volume

84

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