The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons.

dc.contributor.author

Horita, Haruhito

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Wada, Kazuhiro

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Rivas, Miriam V

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Hara, Erina

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Jarvis, Erich D

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United States

dc.date.accessioned

2015-12-22T04:27:47Z

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2010-07-15

dc.description.abstract

Many immediate early genes (IEGs) have activity-dependent induction in a subset of brain subdivisions or neuron types. However, none have been reported yet with regulation specific to thalamic-recipient sensory neurons of the telencephalon or in the thalamic sensory input neurons themselves. Here, we report the first such gene, dual specificity phosphatase 1 (dusp1). Dusp1 is an inactivator of mitogen-activated protein kinase (MAPK), and MAPK activates expression of egr1, one of the most commonly studied IEGs, as determined in cultured cells. We found that in the brain of naturally behaving songbirds and other avian species, hearing song, seeing visual stimuli, or performing motor behavior caused high dusp1 upregulation, respectively, in auditory, visual, and somatosensory input cell populations of the thalamus and thalamic-recipient sensory neurons of the telencephalic pallium, whereas high egr1 upregulation occurred only in subsequently connected secondary and tertiary sensory neuronal populations of these same pathways. Motor behavior did not induce high levels of dusp1 expression in the motor-associated areas adjacent to song nuclei, where egr1 is upregulated in response to movement. Our analysis of dusp1 expression in mouse brain suggests similar regulation in the sensory input neurons of the thalamus and thalamic-recipient layer IV and VI neurons of the cortex. These findings suggest that dusp1 has specialized regulation to sensory input neurons of the thalamus and telencephalon; they further suggest that this regulation may serve to attenuate stimulus-induced expression of egr1 and other IEGs, leading to unique molecular properties of forebrain sensory input neurons.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/20506480

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1096-9861

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https://hdl.handle.net/10161/11258

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eng

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Wiley

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J Comp Neurol

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10.1002/cne.22370

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Animals

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Auditory Perception

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Avian Proteins

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Brain

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Columbidae

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Dual Specificity Phosphatase 1

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Early Growth Response Protein 1

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Gene Expression Regulation

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Male

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Melopsittacus

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Mice

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Motor Activity

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Neurons, Afferent

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Songbirds

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Species Specificity

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Telencephalon

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Thalamus

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Visual Perception

dc.title

The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons.

dc.type

Journal article

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/20506480

pubs.begin-page

2873

pubs.end-page

2901

pubs.issue

14

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Basic Science Departments

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Duke

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Duke Institute for Brain Sciences

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Institutes and Provost's Academic Units

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Neurobiology

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School of Medicine

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University Institutes and Centers

pubs.publication-status

Published

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518

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