A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.

dc.contributor.author

Wang, Meng-Yun

dc.contributor.author

He, Jing

dc.contributor.author

Zhu, Mei-Ling

dc.contributor.author

Teng, Xiao-Yan

dc.contributor.author

Li, Qiao-Xin

dc.contributor.author

Sun, Meng-Hong

dc.contributor.author

Wang, Xiao-Feng

dc.contributor.author

Yang, Ya-Jun

dc.contributor.author

Wang, Jiu-Cun

dc.contributor.author

Jin, Li

dc.contributor.author

Wang, Ya-Nong

dc.contributor.author

Wei, Qing-Yi

dc.date.accessioned

2019-02-01T15:28:09Z

dc.date.available

2019-02-01T15:28:09Z

dc.date.issued

2016-01-28

dc.date.updated

2019-02-01T15:28:06Z

dc.description.abstract

AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric cancer (GCa) risk in a case-control study of 1,110 GCa patients and 1,114 matched cancer-free controls. We genotyped five SNPs (AKT1 rs2494750G >C, AKT1 rs2494752A >G, AKT1 rs10138227C >T, AKT2 rs7254617G>A and AKT2 rs2304186G >T) located in the 5' upstream regulatory, first intron or promoter regions. In the logistic regression analysis, a significantly elevated GCa risk was associated with the rs2494752 AG/GG variant genotypes (adjusted odds ratio [OR] = 1.20, 95% confidence interval [CI] = 1.02-1.42) under a dominant genetic model, and this risk was more evident in subgroups of ever drinkers. The luciferase reporter assay showed that the rs2494752 G allele significantly increased luciferase activity. Our results suggest that the potentially functional AKT1 rs2494752 SNP may affect GCa susceptibility, likely by modulating the AKT1 promoter transcriptional activity. Larger, independent studies are warranted to validate our findings.

dc.identifier

srep20008

dc.identifier.issn

2045-2322

dc.identifier.issn

2045-2322

dc.identifier.uri

https://hdl.handle.net/10161/18025

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Scientific reports

dc.relation.isversionof

10.1038/srep20008

dc.subject

Humans

dc.subject

Adenocarcinoma

dc.subject

Stomach Neoplasms

dc.subject

Genetic Predisposition to Disease

dc.subject

Neoplasm Staging

dc.subject

Risk Factors

dc.subject

Case-Control Studies

dc.subject

Transcription, Genetic

dc.subject

Gene Expression Regulation, Neoplastic

dc.subject

Genotype

dc.subject

Linkage Disequilibrium

dc.subject

Polymorphism, Single Nucleotide

dc.subject

Alleles

dc.subject

Adult

dc.subject

Aged

dc.subject

Aged, 80 and over

dc.subject

Middle Aged

dc.subject

Asian Continental Ancestry Group

dc.subject

China

dc.subject

Female

dc.subject

Male

dc.subject

Proto-Oncogene Proteins c-akt

dc.subject

Promoter Regions, Genetic

dc.subject

Young Adult

dc.subject

Genetic Association Studies

dc.title

A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.

dc.type

Journal article

duke.contributor.orcid

Wei, Qing-Yi|0000-0002-3845-9445|0000-0003-4115-4439

pubs.begin-page

20008

pubs.issue

1

pubs.organisational-group

School of Medicine

pubs.organisational-group

Duke

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Population Health Sciences

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Medicine, Medical Oncology

pubs.organisational-group

Medicine

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

6

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.pdf
Size:
473.5 KB
Format:
Adobe Portable Document Format